UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

(RULE 14a-101)

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No.    )

Filed by the Registrant  ☒

Filed by a Party other than the Registrant  ☐

Check the appropriate box:

SANA BIOTECHNOLOGY, INC.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check all boxes that apply):

Sana Biotechnology, Inc. Important Notice Regarding the Availability of Proxy Materials Annual Meeting of Stockholders to be held on June 6, 2022 For stockholders of record as of April 8, 2022 This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the information contained in the proxy materials before voting. To view the proxy materials, and to obtain information on how to vote, and how to attend and participate in the Annual Meeting, visit: www.proxydocs.com/SANA. To vote your proxy while visiting this website, you will need the 12-digit control number in the shaded box below. Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the internet. P.O. BOX 8016, CARY, NC 27512-9903 For a convenient way to view proxy materials and VOTE, go to www.proxydocs.com/SANA Have the 12-digit control number located in the shaded box above available when you access the website and follow the instructions. You may request a paper copy of the proxy materials. There is no charge to you for requesting a copy. In order to receive a paper copy of the proxy materials in time for this year’s meeting, you must request a copy on or before May 27, 2022 at 2:00 PM, Pacific Time. To order a paper copy of the proxy materials, use one of the following methods. www.investorelections. INTERNET com/SANA TELEPHONE (866) 648-8133 E-MAIL paper@investorelections.com When requesting materials via the Internet, you will need the 12-digit control number located in the shaded box above. When requesting materials via the telephone, you will need the 12-digit control number located in the shaded box above. If requesting materials by e-mail, please send a blank e-mail with the 12-digit control number (located in the shaded box above) in the subject line. No other requests, instructions or other inquiries should be included in your e-mail. Sana Biotechnology, Inc. Meeting Type: Annual Meeting of Stockholders Date: Monday, June 6, 2022 Time: 9:00 AM, Pacific Time Place: The Annual Meeting will be a virtual meeting conducted via live audio webcast. Please visit www.proxydocs.com/SANA for registration details. You must register at www.proxydocs.com/SANA to attend and participate in the Annual Meeting online. SEE REVERSE FOR FULL AGENDA

Sana Biotechnology, Inc. Annual Meeting of Stockholders THE BOARD OF DIRECTORS RECOMMENDS A VOTE: FOR each nominee for election for Proposal 1 and FOR Proposal 2 PROPOSAL 1. To elect four Class I directors to our Board of Directors, each to serve for a three-year term expiring at the 2025 annual meeting of stockholders. The four nominees for election are: 1.01 Douglas Cole, M.D. 1.02 Steven D. Harr, M.D. 1.03 Michelle Seitz, CFA 1.04 Patrick Y. Yang, Ph.D. 2. To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2022. NOTE: Stockholders will also consider and act upon any other matters which may properly come before the Annual Meeting or any adjournment or postponement thereof.