UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

(RULE 14a-101)

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No.    )

Filed by the Registrant  ☒

Filed by a Party other than the Registrant  ☐

Check the appropriate box:

SANA BIOTECHNOLOGY, INC.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check all boxes that apply):

SANA BIOTECHNOLOGY, INC.

188 East Blaine Street, Suite 400

Seattle, Washington 98102

NOTICE OF 2022 ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD ON JUNE 6, 2022

Notice is hereby given that the 2022 Annual Meeting of Stockholders (the Annual Meeting) of Sana Biotechnology, Inc. will be held on June 6, 2022, at 9:00 a.m., Pacific Time. Due in part to the continuing public health impact of the COVID-19 pandemic, and to support the health and well-being of our stockholders, employees, and communities, the Annual Meeting will be a virtual meeting conducted via live audio webcast. You will not be able to attend the Annual Meeting physically.

To be admitted to and participate in the Annual Meeting, you must register prior to June 3, 2022 at 2:00 p.m., Pacific Time, at www.proxydocs.com/SANA. As part of the registration process, you will be required to enter the control number included on your Notice of Internet Availability of Proxy Materials (Notice) or on your proxy card or voter instruction form, as applicable, if you are receiving a printed copy of our proxy materials. After completing your registration, you will receive further instructions via email prior to the start of the Annual Meeting, including a unique link that will allow you to access the Annual Meeting. Please see the “General Information” section of the attached proxy statement for more details regarding the logistics of the virtual Annual Meeting, including the ability of stockholders to submit questions prior to and during the Annual Meeting and technical details related to accessing the virtual platform. Please monitor our Annual Meeting website at www.proxydocs.com/SANA for updated information regarding the Annual Meeting.

The purpose of the Annual Meeting is the following:

The record date for the Annual Meeting is April 8, 2022. Only stockholders of record at the close of business on that date will be entitled to vote at the Annual Meeting or any adjournment or postponement thereof.

A list of registered stockholders as of the record date will be available for inspection by stockholders of record for any legally valid purpose related to the Annual Meeting (i) during the Annual Meeting by following the instructions provided to you via email prior to the Annual Meeting, if you have registered to attend the Annual Meeting, and (ii) for a period of 10 days prior to the Annual Meeting by sending a request to stockholderlist@sana.com.

We are pleased to take advantage of Securities and Exchange Commission rules that allow companies to furnish their proxy materials over the Internet. We are mailing the Notice to most of our stockholders instead of providing a printed copy of our proxy materials, including our Annual Report on Form 10-K for the fiscal year ending December 31, 2021 (Annual Report). The Notice contains instructions on how to access our proxy materials and to cast your vote. The Notice also contains instructions on how to request a printed copy of our proxy materials. This process allows us to provide our stockholders with the information they need on a timely basis while reducing the environmental impact and lowering the costs of printing and distributing our proxy materials.

Your vote is important. Information on how to vote is discussed in the attached proxy statement. To ensure that your vote is recorded promptly, please vote as soon as possible, even if you plan to attend the Annual Meeting, by voting via the Internet or by telephone, as described in the attached proxy statement, or, if you are receiving a printed copy of our proxy materials, by signing, dating, and returning your completed proxy card or voter instruction form, as applicable. If you are voting via the Internet or by telephone, you will be asked to provide your control number included in the Notice, or, if you are receiving a printed copy of our proxy materials, on your proxy card or voter instruction form, as applicable. Voting in advance of the Annual Meeting will not prevent you from attending the Annual Meeting and voting during the Annual Meeting. Please note, however, that if your shares are held of record by a broker, bank, or other agent, you must obtain a legal proxy issued in your name from that record holder and provide it to us in advance in order to vote during the Annual Meeting.

On behalf of the Board and the employees of Sana Biotechnology, Inc., we thank you for your continued support and participation.

Table of Contents

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SANA BIOTECHNOLOGY, INC.

188 East Blaine Street, Suite 400

Seattle, Washington 98102

PROXY STATEMENT

FOR THE 2022 ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD ON JUNE 6, 2022

This proxy statement contains information about the 2022 Annual Meeting of Stockholders (the Annual Meeting) of Sana Biotechnology, Inc., which will be held on June 6, 2022 at 9:00 a.m., Pacific Time. The Board of Directors of Sana Biotechnology, Inc. (our Board) is using this proxy statement to solicit proxies for use at the Annual Meeting. Any reference to our Annual Meeting in this proxy statement also refers, as applicable, to any adjournment or postponement thereof. In this proxy statement, the terms “Sana,” “we,” “us,” and “our” refer to Sana Biotechnology, Inc. The mailing address of our principal executive offices is Sana Biotechnology, Inc., 188 East Blaine Street, Suite 400, Seattle, Washington 98102.

Due in part to the continuing public health impact of the COVID-19 pandemic, and to support the health and well-being of our stockholders, employees, and communities, the Annual Meeting will be a virtual meeting conducted via live audio webcast. You will not be able to attend the Annual Meeting physically. Instructions on how to attend and participate in the Annual Meeting are described in this proxy statement.

All properly submitted proxies will be voted in accordance with the instructions contained in those proxies. If no instructions are specified, the proxies will be voted in accordance with the recommendation of our Board with respect to each of the matters to be voted on at the Annual Meeting. You may revoke your proxy before it is exercised at the Annual Meeting as described in the “General Information” section of this proxy statement.

We made this proxy statement and our Annual Report on Form 10-K for the fiscal year ended December 31, 2021 (Annual Report) available to stockholders on or about April 26, 2022.

We are an “emerging growth company” under applicable federal securities laws and are, therefore, permitted to comply with certain reduced public company reporting requirements. As an emerging growth company, we provide in this proxy statement the scaled disclosure permitted under the Jumpstart Our Business Startups Act of 2012 (the JOBS Act), including the compensation disclosures required of a “smaller reporting company,” as that term is defined in Rule 12b-2 promulgated under the Securities Exchange Act of 1934, as amended (the Exchange Act). In addition, as an emerging growth company, we are not required to conduct votes seeking approval, on an advisory basis, of the compensation of our named executive officers or the frequency with which such votes must be conducted. We will remain an “emerging growth company” until the earliest of (i) the last day of the fiscal year following the fifth anniversary of our initial public offering; (ii) the last day of the fiscal year in which our total annual gross revenue is equal to or more than $1.07 billion; (iii) the date on which we have issued more than $1 billion in nonconvertible debt during the previous three years; or (iv) the date on which we are deemed to be a large accelerated filer under the rules of the Securities and Exchange Commission (SEC). Even after we are no longer an “emerging growth company,” we may be a “smaller reporting company.”

IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS FOR

THE ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON JUNE 6, 2022:

The Notice of 2022 Annual Meeting of Stockholders, this proxy statement, and our Annual Report are available for viewing, printing, and downloading free of charge at www.proxydocs.com/SANA.

A copy of our Annual Report, as filed with the SEC, excluding exhibits, will be furnished free of charge to any stockholder upon written request to Sana Biotechnology, Inc., 188 East Blaine Street, Suite 400, Seattle, Washington 98102, Attention: Corporate Secretary. This proxy statement and our Annual Report are also available on the SEC’s website free of charge at www.sec.gov.

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SANA BIOTECHNOLOGY, INC.

PROXY STATEMENT

FOR THE 2022 ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD ON JUNE 6, 2022

GENERAL INFORMATION

When are this proxy statement and the accompanying materials scheduled to be sent to stockholders?

We have elected to provide our stockholders with access to our proxy materials (Proxy Materials) via the Internet. Accordingly, on or about April 26, 2022, we began mailing to stockholders a Notice of Internet Availability of Proxy Materials (the Notice). Our Proxy Materials were mailed or made available to stockholders via the Internet on or about the same date. Our Proxy Materials include the Notice of 2022 Annual Meeting of Stockholders, this proxy statement, our Annual Report on Form 10-K for the fiscal year ending December 31, 2021 (our Annual Report), and, if you are receiving a printed copy of the Proxy Materials, the accompanying proxy card or, for shares held in street name (i.e., held for your account by a broker, bank, or other agent), a voter instruction form.

Why did I receive a Notice of Internet Availability of Proxy Materials instead of a full set of proxy materials?

Pursuant to rules adopted by the Securities and Exchange Commission (SEC), for most stockholders, we are providing access to our Proxy Materials via the Internet rather than printing and mailing our Proxy Materials. We believe following this process will expedite stockholders’ receipt of such Proxy Materials and lower the costs and reduce the environmental impact of providing our Proxy Materials to stockholders. Therefore, the Notice was mailed to holders of record and beneficial owners of our common stock starting on or about April 26, 2022. The Notice provides instructions on how stockholders may access and view our Proxy Materials or, alternatively, how stockholders may request to receive a printed copy of our Proxy Materials, including a proxy card or voter instruction form, as applicable. The Notice also provides instructions on how to vote your shares, including how to access any website referred to in the Notice for purposes of voting your shares. In addition, stockholders of record may request to receive our Proxy Materials in printed form by mail or electronically by email on an ongoing basis for future stockholder meetings. Please note that, while our Notice of 2022 Annual Meeting of Stockholders, this proxy statement, and our Annual Report are available at the website referenced in the Notice and on our corporate website, no other information contained on either website is incorporated by reference in or considered to be a part of this proxy statement.

Where and when is the Annual Meeting?

The Annual Meeting will be held on June 6, 2022 at 9:00 a.m., Pacific Time. Due in part to the continuing public health impact of the COVID-19 pandemic, and to support the health and well-being of our stockholders, employees, and communities, the Annual Meeting will be a virtual meeting conducted via live audio webcast. You will not be able to attend the Annual Meeting physically. To be admitted to and participate in the Annual Meeting, you must register by June 3, 2022 at 2:00 p.m., Pacific Time, at www.proxydocs.com/SANA. As part of the registration process, you will be required to enter the control number included in the Notice, or, if you are receiving a printed copy of our Proxy Materials, on your proxy card or voter instruction form, as applicable. After completing your registration, you will receive further instructions via email prior to the start of the Annual Meeting, including a unique link that will allow you access to the Annual Meeting. Please be sure to follow the instructions for registration found in the Notice and subsequent instructions that will be delivered to you via email following registration.

You will have the ability to submit questions during the registration process for the Annual Meeting, and you may submit additional questions by modifying your registration information following registration. You may also submit questions during the Annual Meeting through the Annual Meeting website. The Annual Meeting agenda

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and rules of conduct will be available for viewing on the Annual Meeting website. Subject to the rules of conduct, we will provide answers to questions relating to matters properly brought before the Annual Meeting during the Annual Meeting.

Technical assistance will be available one hour prior to and during the Annual Meeting. Information related to technical assistance will be provided to you in the email with the login instructions for the Annual Meeting. You will be able to log in to the Annual Meeting 15 minutes prior to the start of the Annual Meeting. We recommend that you log in early to ensure you are logged in when the Annual Meeting starts. You will be able to vote during the Annual Meeting, as further described in the section below titled “How do I vote?”

Who is soliciting my vote?

Our Board of Directors (our Board) is soliciting your vote for the Annual Meeting.

Who can vote at the Annual Meeting?

Only stockholders of record as of the close of business on the record date of April 8, 2022 will be entitled to vote at the Annual Meeting. On this date, there were 189,608,973 shares of common stock issued and outstanding and entitled to vote.

What is the quorum requirement?

A quorum of stockholders is necessary to hold a valid meeting of stockholders. A quorum will be present if stockholders holding at least a majority of our outstanding shares of common stock entitled to vote at the Annual Meeting are present at the Annual Meeting in person (via the Internet) or represented by proxy.

We will count your shares towards the quorum only if you submit a valid proxy card or voter instruction form, as applicable, vote via the Internet or over the telephone prior to the Annual Meeting, or attend the Annual Meeting. We will count abstentions and broker non-votes toward the quorum requirement. If there is no quorum, the chair of the Annual Meeting or the holders of a majority of shares present at the Annual Meeting in person (via the Internet) or represented by proxy may adjourn the Annual Meeting to another date.

What am I voting on and how many votes are needed to approve or take action with respect to each proposal?

Proposal 1: Election of Directors. Directors will be elected by a plurality of the votes cast at the Annual Meeting by the holders of shares present in person (via the Internet) or represented by proxy and entitled to vote on the election of directors. “Plurality” means that the individuals who receive the largest number of “For” votes cast are elected as directors, up to the maximum number of directors to be elected at the Annual Meeting. Accordingly, the four nominees receiving the most “For” votes will be elected as directors. Abstentions and broker non-votes will not affect the outcome of the election of directors. In tabulating the voting results for the election of directors, only “For” and “Withhold” votes will be counted. You may not vote your shares cumulatively for the election of directors.

Proposal 2: Ratification of Appointment of Independent Registered Public Accounting Firm. The ratification of Ernst & Young LLP (EY) as our independent registered public accounting firm for the fiscal year ending December 31, 2022 will require “For” votes from a majority of the votes cast at the Annual Meeting by the holders of shares present in person (via the Internet) or represented by proxy and entitled to vote on this proposal. Abstentions and broker non-votes will not affect the outcome of the vote on this proposal.

If there are insufficient votes to approve either or both of Proposals 1 or 2, your proxy may be voted by the persons named in the proxy to adjourn the Annual Meeting in order to solicit additional proxies in favor of the

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approval of such proposal(s). If the Annual Meeting is adjourned or postponed for any reason, at any subsequent reconvening of the Annual Meeting, your proxy will be voted in the same manner as it would have been voted at the original convening of the Annual Meeting, unless you revoke your proxy. Your proxy may be voted in this manner even though it may have been voted on the same or any other matter at a previous session of the Annual Meeting.

How do I vote?

For Proposal 1, you may either vote “For” any or all of the nominees to our Board, or you may “Withhold” your vote for any nominee you specify. For Proposal 2, you may vote “For” or “Against” ratifying the appointment of EY as our independent registered public accounting firm for the fiscal year ending December 31, 2022, or you may abstain from voting.

The procedures for voting differ depending on whether you hold your shares as a stockholder of record or as a beneficial owner of shares held in “street name.” The procedures for voting in each of these cases are described below.

Stockholder of Record: Shares Registered in Your Name

If on April 8, 2022 your shares were registered directly in your name with our transfer agent, American Stock Transfer & Trust Company, LLC, then you are a stockholder of record. As a stockholder of record, you may vote in any of the following ways:

Whether or not you plan to attend the Annual Meeting, we urge you to vote via the Internet, by telephone, or, if you are receiving a printed copy of our Proxy Materials, by mail, as instructed above, to ensure your vote is counted. You may still attend and vote during the Annual Meeting even if you have already voted prior to the Annual Meeting.

If you are receiving a printed copy of our Proxy Materials, and you sign the enclosed proxy card but do not make specific choices, the persons named in your proxy will vote your shares “For” all nominees in Proposal 1 and “For” Proposal 2, as set forth above and in the Notice of 2022 Annual Meeting of Stockholders. If any other matter is presented, the persons named in the proxy will vote as recommended by our Board or, if our Board does not make a recommendation, in their own discretion based on the company’s and our stockholders’ best interests. As of the date of this proxy statement, we know of no matters that may be presented at the Annual Meeting other than those listed in the Notice of 2022 Annual Meeting of Stockholders.

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Beneficial Owner: Shares Registered in the Name of Broker, Bank, or Other Agent

If on April 8, 2022 your shares were not held in your name, but rather in an account at a broker, bank, or other agent, then you are the beneficial owner of shares held in “street name.” The organization holding your account is considered to be the stockholder of record for purposes of voting at the Annual Meeting.

As a beneficial owner, you will receive voting instructions from the broker, bank, or other agent that holds your shares. Please follow these instructions in order to vote your shares.

Generally, as a beneficial owner, you will have the ability to vote in the following ways:

Whether or not you plan to attend the Annual Meeting, we urge you to vote via the Internet, by telephone, or, if you are receiving a printed copy of our Proxy Materials, by mail, as instructed above, to ensure your vote is counted. You may still attend and vote during the Annual Meeting even if you have already voted.

If you are receiving a printed copy of our Proxy Materials, and you sign and submit the enclosed voter instruction form but do not make specific choices, the organization holding your account will be able to vote your shares in its discretion for Proposal 2, but not for Proposal 1. For additional information, see the section below titled “What are broker non-votes?”

How do I revoke my proxy?

If you are a stockholder of record, you may revoke your proxy by:

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If you are a beneficial owner of your shares, you may revoke your proxy by:

Please note that your personal attendance at the Annual Meeting, in and of itself, will not revoke your proxy. Your last vote, whether cast prior to or during the Annual Meeting, is the vote that we will count.

What are broker non-votes?

Broker non-votes occur when a beneficial owner of shares held in street name submits his or her signed voter instruction form, but does not give instructions to the broker, bank, or agent holding the shares as to how to vote on matters deemed “non-routine.” Generally, if shares are held in street name, the beneficial owner of the shares is entitled to give voting instructions to the broker, bank, or agent holding the shares. If the beneficial owner submits his or her signed voter instruction form, but does not provide voting instructions, the broker, bank, or agent may vote the shares with respect to matters that are considered to be “routine,” but may not vote the shares with respect to “non-routine” matters. In the event a beneficial owner of shares held in street name does not submit a voter instruction form or otherwise vote by one of the methods described above, then the broker, bank, or agent holding such beneficial owner’s shares may vote the shares in its discretion to the extent permitted by The Nasdaq Marketplace Rules (the Nasdaq Listing Rules). Proposal 1 is considered “non-routine,” and Proposal 2 is considered “routine” under the Nasdaq Listing Rules.

How many votes do I have?

On each matter to be voted upon, you have one vote for each share of common stock you own as of the close of business on April 8, 2022.

What does it mean if I receive more than one Notice, proxy card, or voter instruction form?

You may receive more than one Notice, or if you are receiving a paper copy of our Proxy Materials, more than one proxy card or voter instruction form, as applicable, if your shares are registered in more than one name or are registered in different accounts. Please make sure to vote all shares covered by each such Notice, proxy card, or voter instruction form, to ensure that all your shares are voted.

How does the Board recommend that I vote my shares?

Our Board’s recommendations are set forth together with the description of each proposal in this proxy statement. Our Board recommends a vote:

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Unless you give other instructions when you submit your vote, including via the Internet, by telephone, or on your proxy card or voter instruction form, as applicable, your shares will be voted in accordance with the recommendations of our Board. With respect to any other matter that properly comes before the Annual Meeting, the designated proxy holders will vote as recommended by our Board or, if no recommendation is given, in their own discretion based on the company’s and our stockholders’ best interests. As of the date of this proxy statement, we know of no matters that may be presented at the Annual Meeting other than those listed in the Notice of 2022 Annual Meeting of Stockholders.

Who will bear the expense of soliciting proxies?

We will bear the cost of solicitation of proxies, including preparation, assembly, printing, and mailing of the Notice and our Proxy Materials, as well as any additional information furnished to stockholders, and returning and tabulating the proxies. Copies of solicitation materials will be furnished to brokers, banks, and agents holding in their names shares of our common stock beneficially owned by others to forward to such beneficial owners. We may reimburse persons representing beneficial owners of our common stock for the cost of forwarding solicitation materials to such beneficial owners. In addition to our solicitation of proxies by mail, our directors, officers, or other employees may also solicit proxies in person, by telephone, or by other means of communication. We will not pay any additional compensation to our directors, officers, or other employees for such services.

How can I find the voting results from the Annual Meeting?

We will announce preliminary voting results at our Annual Meeting. We will publish final voting results in a current report on Form 8-K that we expect to file with the SEC no later than June 10, 2022. If final voting results are not available by June 10, 2022, we will disclose the preliminary results in a current report on Form 8-K and, within four business days after the final voting results are known to us, file an amended current report on Form 8-K to disclose the final voting results.

When are stockholder proposals due for the 2023 Annual Meeting of Stockholders?

If you wish to submit proposals for inclusion in our proxy statement for the 2023 annual meeting of stockholders (the 2023 Annual Meeting), we must receive them at our offices on or before December 27, 2022. However, if the date of the 2023 Annual Meeting is moved by more than 30 days from the date that we currently contemplate, then we must receive such proposals within a reasonable time before we begin to print and send proxy materials for the 2023 Annual Meeting. If that happens, we will publicly announce the deadline for submitting a proposal in a press release or in a document filed with the SEC. Nothing in this paragraph shall require us to include in our proxy statement or any other proxy materials for the 2023 Annual Meeting any stockholder proposal that does not meet the requirements of the SEC in effect at the time. Any such proposal will be subject to Rule 14a-8 of the Securities Exchange Act of 1934, as amended (the Exchange Act).

If you wish to nominate a director or submit a proposal for presentation at the 2023 Annual Meeting without including such proposal in next year’s proxy statement, you must be a stockholder of record and provide timely notice in writing to our Corporate Secretary at c/o Sana Biotechnology, Inc., 188 East Blaine Street, Suite 400, Seattle, Washington 98102. To be timely, we must receive the notice not less than 90 days nor more than 120 days prior to the first anniversary of the Annual Meeting, which is between February 6, 2023 and March 8, 2023; provided, however, that in the event the date of the 2023 Annual Meeting is more than 30 days before or more than 60 days after such anniversary date, we must receive your notice (a) no earlier than the close of business on the 120th day prior to the 2023 Annual Meeting and (b) no later than the close of business on the later of the 90th day prior to the 2023 Annual Meeting or the 10th day following the day on which we first make a public announcement of the date of the 2023 Annual Meeting. Your written notice must contain specific information required in Section 2.5 of our amended and restated bylaws (our bylaws). For additional information about our director nomination requirements, please see our bylaws.

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How can I get additional information about the company?

We file annual, quarterly, and current reports, proxy statements, and other information with the SEC. We maintain a website at www.sana.com and the SEC maintains a website at www.sec.gov where you can access these reports, proxy statements, and other information regarding our company. Information contained on our or the SEC website is not part of our proxy soliciting materials.

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PROPOSAL 1

ELECTION OF DIRECTORS

General

Our Board currently comprises ten directors. Our amended and restated certificate of incorporation (our certificate of incorporation) provides for a classified Board consisting of three classes of directors. Class I currently consists of four directors, each of whom has been nominated and is standing for re-election at the Annual Meeting. Classes II and III each currently consist of three directors. Each class serves a staggered three-year term. At each annual meeting of stockholders, the successors to directors whose terms then expire are elected to serve from the time of election and qualification until the third annual meeting following their election. Vacancies on our Board may be filled only by an affirmative vote of a majority of the directors then in office. A director elected by our Board to fill a vacancy in a class, including vacancies created by an increase in the number of directors, serves for the remainder of the full term of that class and until the director’s successor is duly elected and qualified.

Our Board has nominated the four individuals listed in the table below for election as Class I directors at the Annual Meeting. If our stockholders elect the nominees listed below, they will hold office until the annual meeting of stockholders in 2025 or until their successors have been duly elected and qualified. All nominees are currently serving on our Board and have consented to being named in this proxy statement and to serve if elected. Proxies may not be voted for any nominees other than those named below.

If any nominee is unable or does not qualify to serve, you or your proxy may vote for another nominee proposed by our Board. If for any reason any of these nominees proves unable or unwilling to stand for election or ceases to qualify to serve as a director, our Board will nominate an alternate or reduce the size of our Board to eliminate any resulting vacancies. Our Board has no reason to believe that any of the nominees would prove unable to serve if elected. There are no arrangements or understandings between us and any director, or nominee for directorship, pursuant to which such person was selected as a director or nominee.

We seek directors with a broad range of qualifications, skills, and experience that would enhance Board effectiveness and strengthen our Board’s ability to carry out its oversight role on behalf of stockholders. Though we do not have a specific policy with respect to Board diversity, we consider diversity as one of many relevant factors when evaluating potential directors. As further described below, we consider diversity broadly when evaluating potential directors and may also consider factors such as a candidate’s relevant academic expertise and business or career experience, including experience in corporate management or as a board member or executive officer of another publicly traded company, to be relevant. In addition, we seek directors who have a high level of personal and professional integrity, strong ethics and values, and the ability to make mature, independent business judgments.

Information About Our Nominees For Election

Set forth below are the names, ages, and lengths of service of our nominees for election to our Board.

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Biographical information for each nominee for election to our Board, including each such individual’s principal occupation, business experience, and education, and an explanation of the qualifications, skills, and experience that we believe are relevant to such individual’s service on our Board, are set forth below. Unless otherwise indicated, principal occupations shown for each nominee for election have extended for five or more years.

Douglas Cole, M.D. has served as a member of our Board since April 2020. Dr. Cole joined Flagship Pioneering, which conceives, creates, resources, and develops first-in-category bioplatform companies, in 2001, and is currently a Managing Partner focused on life science investments. Dr. Cole currently serves on the boards of directors of Denali Therapeutics Inc. (Denali), Foghorn Therapeutics Inc., and Sigilon Therapeutics, Inc., each of which is a public biotechnology company, and on the boards of directors of a number of private companies. In the past five years, Dr. Cole served on the boards of directors of Quanterix Corporation, a public life sciences company, and Editas Medicine, Inc., a public biotechnology company. Dr. Cole received his M.D. from the University of Pennsylvania School of Medicine and his B.A. in English from Dartmouth College. We believe Dr. Cole is qualified to serve on our Board because of his substantial experience as an investor in emerging biopharmaceutical and life sciences companies as well as his experience serving on the boards of directors of multiple public and private biopharmaceutical companies.

Steven D. Harr, M.D. has served as our President and Chief Executive Officer since September 2018 and has served as a member of our Board since October 2018. Prior to Sana, Dr. Harr served as Chief Financial Officer and Head of Corporate Development at Juno Therapeutics, Inc. (Juno), a biopharmaceutical company focused on developing cancer immunotherapies, from April 2014 until its acquisition by Celgene Corporation (Celgene), a public biopharmaceutical company (later acquired by Bristol-Myers Squibb Company), in March 2018. At Juno, Dr. Harr was responsible for the overall financial and operational strategy of the company. Prior to Juno, Dr. Harr was Managing Director and Head of Biotechnology Investment Banking at Morgan Stanley, a public multinational investment bank and financial services company, from May 2010 until April 2014, and prior to his investment banking role was the Lead Biotech Research Analyst and Co-head of Global Healthcare Research at Morgan Stanley. Dr. Harr previously served as a member of the boards of directors of Loxo Oncology, Inc. (Loxo), which was a public biopharmaceutical company during Dr. Harr’s service as a director, until its acquisition by Eli Lilly and Company (Eli Lilly), and JW (Cayman) Therapeutics Co. Ltd (JW Therapeutics), a public cell therapy company in China that he co-founded. Dr. Harr received his B.A. in Economics from the College of the Holy Cross and his M.D. from the Johns Hopkins University School of Medicine. Dr. Harr completed his residency in internal medicine at the University of California, San Francisco. We believe Dr. Harr is qualified to serve on our Board because of his extensive management and leadership experience with biopharmaceutical and life sciences companies.

Michelle Seitz, CFA has served as a member of our Board since November 2020. Ms. Seitz has served as Chief Executive Officer of Russell Investments, a global investment solutions provider, since September 2017, and as Chair since January 2018. Prior to Russell Investments, Ms. Seitz worked in various positions at William Blair, a global investment banking and wealth management firm, from February 1996 to August 2017, most recently serving as the Chief Executive Officer of William Blair Investment Management, Chair and President of William Blair Funds, and as a member of the board of directors from June 2001 to August 2017. Ms. Seitz currently serves on the board of directors of the Washington Roundtable, the Dean’s Council of Kelley School of Business at Indiana University, and the ICI Board of Governors, and as Co-Chair of Challenge Seattle, an alliance of chief executive officers of multinational companies within the Seattle region. Ms. Seitz previously served as a director of the Financial Accounting Foundation, which provides oversight of Financial Accounting Standards Board (FASB) and Governmental Accounting Standards Board (GASB). Ms. Seitz received her B.S. in Accounting from the Indiana University Kelley School of Business and her Chartered Financial Analyst designation. We believe Ms. Seitz is qualified to serve on our Board because of her extensive finance and industry experience and her experience serving on various boards of directors.

Patrick Y. Yang, Ph.D. has served as a member of our Board since October 2018. Dr. Yang served as Executive Vice President and Special Advisor of Juno from September 2017 to January 2019. Since 2013, Dr. Yang has

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served as a biotechnology and biopharmaceutical industry consultant. From January 2010 to March 2013, Dr. Yang served as Executive Vice President and Global Head of Technical Operations for F. Hoffmann-La Roche Ltd. (Roche), a healthcare company, where he was responsible for the company’s pharmaceutical process development, engineering, quality, technical regulatory, supply chain, and all manufacturing plants. Before joining Roche, Dr. Yang worked for each of Genentech, Inc. (Genentech), a biotechnology company, Merck & Co., Inc. (Merck), a public pharmaceutical company, General Electric Company (General Electric), a public industrial company, and Life Systems, Inc., a life science research and development company, during which time he developed significant experience with pharmaceuticals and biotechnology manufacturing, engineering, technology, and supply chain management. Dr. Yang serves on the boards of directors of Amyris, Inc. and Codexis, Inc., each of which is a public biotechnology company. Dr. Yang previously served on the board of directors of Tesoro Corporation, a public independent petroleum refining and marketing company. Dr. Yang received his B.S. in Engineering from the National Chiaotung University in Taiwan, his M.Sc. in Electrical Engineering from the University of Cincinnati, and his Ph.D. in Engineering from the Ohio State University. We believe Dr. Yang is qualified to serve on our Board because of his extensive background and expertise in the biotechnology industry and his previous and current experience serving on various public company boards of directors.

Vote Required

Directors are elected by a plurality of the votes cast at the Annual Meeting by the holders of shares present in person (via the Internet) or represented by proxy and entitled to vote on the election of directors. The four nominees receiving the most “For” votes will be elected as directors. In tabulating the voting results for the election of directors, only “For” and “Withhold” votes will be counted. Abstentions and broker non-votes will not have any effect on the outcome of the election of directors. You may not vote your shares cumulatively for the election of directors. Shares represented by executed proxies will be voted, if authority to do so is not withheld, “For” the election of the four nominees named above. If any nominee becomes unavailable for election as a result of an unexpected occurrence, your shares will be voted for the election of a substitute nominee proposed by our Board.

Our Recommendation

OUR BOARD UNANIMOUSLY RECOMMENDS A VOTE “FOR” EACH OF THE NOMINEES SET FORTH ABOVE.

Information About Our Board of Directors

Our nominees for election as directors at our Annual Meeting are all currently serving as members of our Board. Information about each such nominee is set forth in the section above titled “Information About Our Nominees for Election” and is incorporated into this section by reference.

Set forth below are the names, ages, and lengths of service of the remaining members of our Board whose terms continue beyond the Annual Meeting.

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Biographical information for each continuing director, including each such individual’s principal occupation, business experience, and education, and an explanation of the qualifications, skills, and experience that we believe are relevant to such individual’s service on our Board, are set forth below. Unless otherwise indicated, principal occupations shown for each continuing director have extended for five or more years.

Hans E. Bishop has served as a member of our Board since October 2018. Mr. Bishop has more than 30 years of experience in the biotechnology industry. Mr. Bishop is a founder of and has served as President of Altos Labs, Inc. (Altos Labs), a private biotechnology company, since January 2022. Prior to Altos Labs, Mr. Bishop served as the Chief Executive Officer of GRAIL, Inc., a healthcare company, from June 2019 until October 2021, following its acquisition by Illumina, Inc. (Illumina). Mr. Bishop founded Juno in July 2013 and served as Juno’s President and Chief Executive Officer until its acquisition by Celgene in March 2018. Prior to Juno, Mr. Bishop served as Executive in Residence at Warburg Pincus, a multinational private equity firm. Earlier in his career, Mr. Bishop served as Executive Vice President and Chief Operating Officer for Dendreon Corporation (Dendreon), which was a public biopharmaceutical company developing cancer immunotherapies during his tenure. Prior to Dendreon, Mr. Bishop served as President of Specialty Medicine at Bayer Healthcare, a multinational pharmaceutical and life sciences company, and before that served as Senior Vice President of Global Commercial Operations at Chiron Corporation, which was a multinational biotechnology company, where he was also Vice President and General Manager of European Biopharmaceuticals. He currently serves on the boards of directors of Agilent Technologies, Inc., a public instrumentation manufacturing company, and Lyell Immunopharma, Inc. (Lyell Immunopharma), a public cellular therapy company. Mr. Bishop previously served on the board of directors of Celgene and JW Therapeutics. Mr. Bishop received his B.A. in Chemistry from Brunel University in London. We believe Mr. Bishop is qualified to serve on our Board because of his extensive management experience within the pharmaceutical and biotechnology industries and his academic experience.

Robert Nelsen has served as a member of our Board since October 2018. Mr. Nelsen is a co-founder and has served as Managing Director of ARCH Venture Partners, a venture capital firm focused on early-stage technology companies, since 1994, and has played a significant role in the early sourcing, financing, and development of more than 30 biopharmaceutical companies. Mr. Nelsen currently serves on the boards of directors of several public biotechnology and biopharmaceutical companies, including Brii Biosciences Limited, Denali, Hua Medicine, Lyell Immunopharma, and Vir Biotechnology, Inc. Mr. Nelsen previously served on the boards of directors of several public biotechnology and biopharmaceutical companies, including Adolor Corporation, Agios Pharmaceuticals, Inc., Beam Therapeutics Inc. (Beam), Bellerophon Therapeutics, Inc., Fate Therapeutics, Inc., Illumina, Juno, Karuna Therapeutics, Inc., KYTHERA Biopharmaceuticals, Inc., NeurogesX, Inc., Revolution Healthcare Acquisition Corp., Sage Therapeutics, Inc., Sienna Biopharmaceuticals, Inc., Syros Pharmaceuticals, Inc., and Unity Biotechnology, Inc. He also previously served as Trustee of the Fred Hutchinson Cancer Research Center and as a director of the National Venture Capital Association. Mr. Nelsen received his M.B.A. from the University of Chicago Booth School of Business and his B.S. in Economics and Biology from the University of Puget Sound. We believe Mr. Nelsen is qualified to serve on our Board because of his venture capital and industry experience, his extensive experience serving on boards of directors of public biotechnology companies, and his significant academic experience.

Alise S. Reicin, M.D. has served as a member of our Board since December 2020. Dr. Reicin has served as Chief Executive Officer and President of Tectonic Therapeutic, Inc. (Tectonic), a biotechnology company, since August 2020. Prior to Tectonic, she served as President, Global Clinical Development at Celgene from November 2018 to December 2019. Prior to Celgene, she served as Head of Global Clinical Development at EMD Serono Inc. (EMD Serono), a pharmaceutical company, from May 2015 to October 2018. Prior to EMD Serono, Dr. Reicin served as Vice President, Program and Pipeline Leadership, Oncology at Merck. Prior to Merck, she was a faculty member at Columbia Medical School and a physician and researcher at Columbia Presbyterian Hospital. Dr. Reicin serves on the board of directors of Homology Medicines, Inc., a public biopharmaceutical company. Dr. Reicin received her M.D. from Harvard Medical School and her B.A. in Biochemistry from Barnard College of Columbia University. We believe Dr. Reicin is qualified to serve on our Board because of her extensive clinical expertise and leadership experience at biopharmaceutical companies.

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Joshua H. Bilenker, M.D. has served as a member of our Board since December 2020. Dr. Bilenker is a co-founder of Treeline Biosciences, Inc. (Treeline) and has served as its Chief Executive Officer since April 2021. Prior to Treeline, he served as Chief Executive Officer of Loxo Oncology at Lilly, a research and development group of Eli Lilly, from December 2019 to January 2021, and served as founding Chief Executive Officer of Loxo from July 2013 until its acquisition by Eli Lilly in February 2019. Dr. Bilenker joined Aisling Capital LLC in April 2006 and served there in various capacities, including as an Operating Partner from November 2013 until December 2019. Previously, Dr. Bilenker served as a medical officer in the Office of Oncology Drug Products at the United States Food and Drug Administration from August 2004 to April 2006. Dr. Bilenker serves on the board of directors of Gossamer Bio, Inc., a public biopharmaceutical company, and previously served on the boards of directors of several public companies, including Loxo, ViewRay, Inc., a public medical technology and device company, T2 Biosystems, Inc., a public medical diagnostics company, and Roka Bioscience, Inc., a molecular diagnostics company that was public at the time Dr. Bilenker served on its board of directors. Dr. Bilenker also formerly served on the board of directors of the National Comprehensive Cancer Network Foundation and BioEnterprise. Dr. Bilenker received his M.D. from the Johns Hopkins School of Medicine and his A.B. in English from Princeton University. We believe Dr. Bilenker is qualified to serve on our Board because of his extensive experience and service as a director or officer of, and as an investor in, public biopharmaceutical and life sciences companies.

Richard Mulligan, Ph.D. has served as Executive Vice Chairman of our Board since November 2018 and Head of SanaX since April 2020. Dr. Mulligan served as a consultant to Sana from November 2018 until joining Sana as an employee in April 2020. Dr. Mulligan is currently the Mallinckrodt Professor of Genetics, Emeritus, at Harvard Medical School (Harvard), and has served as Visiting Scientist at the Massachusetts Institute of Technology (MIT) since March 2017. From March 2017 to October 2018, Dr. Mulligan served as Portfolio Manager at Icahn Capital LP, and from May 2013 to December 2016, he was Founding Partner and Senior Managing Director of Sarissa Capital Management LP, a registered investment advisor. From 1996 to 2013, Dr. Mulligan served as the Mallinckrodt Professor of Genetics at Harvard and Director of the Harvard Gene Therapy Initiative. Prior to that, he was Professor of Molecular Biology at MIT, and a member of the Whitehead Institute for Biomedical Research. Dr. Mulligan currently serves on the board of directors of Biogen Inc., a public biotechnology company. We believe Dr. Mulligan is qualified to serve on our Board because of his extensive experience in the biotechnology and life sciences industries and his significant academic experience.

Mary Agnes (Maggie) Wilderotter has served as a member of our Board since May 2020. Ms. Wilderotter has served as the Chief Executive Officer and Chair of the Grand Reserve Inn, a luxury resort and vineyard, since August 2016. From November 2004 to April 2016, Ms. Wilderotter served in a number of roles at Frontier Communications Corporation, a public telecommunications company, including as Executive Chair of the board of directors from April 2015 to April 2016, Chair and Chief Executive Officer from January 2006 to April 2015, and President, Chief Executive Officer, and director from 2004 to 2006. Ms. Wilderotter currently serves on the boards of directors of Lyft, Inc., a public multinational ridesharing company, Costco Wholesale Corporation, a public wholesale retailer, and DocuSign, Inc., a public digital transaction management services company, where she serves as Chair of the board of directors. In addition, Ms. Wilderotter has served on the President’s Commission on Enhancing National Cybersecurity since 2016. Ms. Wilderotter previously served on the boards of directors of a number of public companies across industries, including Hewlett Packard Enterprise Company, a public enterprise information technology company, Cadence Design Systems, Inc., an electronic design automation software and engineering services company, Xerox Corporation, a document management technology solutions company, DreamWorks Animation SKG, Inc., an entertainment company, The Procter & Gamble Company (Procter & Gamble), a consumer goods company, and Juno until its acquisition by Celgene. In addition, Ms. Wilderotter previously served on the President’s National Security Telecommunications Advisory Committee from October 2010 through October 2016, including as Vice Chairman from October 2010 to October 2012 and as Chairman from October 2012 to November 2014. Ms. Wilderotter received her B.A. in Economics from the College of the Holy Cross and an honorary degree from each of Stevens Institute of Technology and the University of Rochester. We believe Ms. Wilderotter is qualified to serve on our Board because of her extensive leadership experience in technology, her expertise in cybersecurity matters, and her service as a director of various public companies.

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Information About Our Executive Officers Who Are Not Directors

The following table sets forth certain information about our executive officers who are not also directors.

The principal occupation, business experience, and education of each executive officer who is not also a director are set forth below.

Sunil Agarwal, M.D. is a co-founder of Sana and has served as our Executive Vice President, Head of Development, and Chief Medical Officer since September 2018. Dr. Agarwal is responsible for the overall strategy and execution of our pipeline, building our development capabilities, and helping to define and execute our overall corporate strategy. Prior to Sana, Dr. Agarwal was the President of Research and Development at Juno from April 2017 to May 2018, where he was responsible for the company’s overall research and development strategy and execution. Prior to Juno, Dr. Agarwal was a partner at Sofinnova Ventures from August 2016 to April 2017. Dr. Agarwal served as Chief Medical Officer and Executive Vice President of Ultragenyx Pharmaceutical Inc. (Ultragenyx), a public biopharmaceutical company, from July 2014 to August 2016, where he was responsible for managing the company’s clinical development and operations, regulatory affairs, biometrics, pharmacovigilance, medical affairs, pharmacology, and toxicology functions. Prior to Ultragenyx, Dr. Agarwal served in various leadership roles at Genentech (later acquired by Roche Holdings, Inc.) from 2003 to 2014, including as Senior Vice President and Global Head of Clinical Development for ophthalmology, metabolism, neurosciences, immunology, and infectious diseases. Dr. Agarwal currently serves on the board of directors for Calithera Biosciences, Inc., a public biotechnology company, and previously served on the board of directors of MyoKardia, Inc., which was a public biopharmaceutical company during Dr. Agarwal’s service as a director. Dr. Agarwal completed his residency at Children’s National Medical Center (CNMC) in Washington, D.C., and practiced in the CNMC Pediatric Emergency Department. He received his B.S. in Neurobiology from Cornell University and his M.D. from Tufts University School of Medicine.

Nathan Hardy is a co-founder of Sana and has served as our Executive Vice President, Chief Financial Officer since February 2021, and previously served as our Senior Vice President, Chief Financial Officer from September 2018 to February 2021. From August 2017 to June 2018, Mr. Hardy served as the Vice President of Finance at Juno, where he led the Business, Financial Planning, and Treasury organizations. Prior to Juno, Mr. Hardy worked at Amgen Inc. (Amgen), a public biopharmaceutical company, from February 2007 to August 2017, where he served in a variety of senior finance and operations leadership positions, culminating as the Executive Director and Head of Corporate Finance. At Amgen, Mr. Hardy helped drive large-scale business transformation and was part of various acquisitions and divestitures. At both Juno and Amgen, Mr. Hardy led resource allocation activities across the organizations. Prior to Amgen, Mr. Hardy held various finance positions at General Electric and Sprint Corporation, which was a public telecommunications company during Mr. Hardy’s tenure. Mr. Hardy received his B.S. in Finance from the University of Utah and his M.B.A. from the University of Notre Dame.

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Christian Hordo has served as our Executive Vice President, Chief Business Officer since February 2021, and previously served as our Senior Vice President, Chief Business Officer from October 2018 to February 2021. Prior to Sana, Mr. Hordo served at Juno as Vice President, Myeloma Program Lead from January 2017 to October 2018 and as Vice President, Head of Business Development from March 2015 to April 2018. At Juno, Mr. Hordo built a team and led negotiations on multiple successfully executed transactions, including a broad strategic collaboration with Celgene. Prior to Juno, Mr. Hordo served in various roles at Genentech, most recently as Project Team Leader from December 2013 to February 2015. Christian received his M.B.A. from Harvard Business School, graduating with high distinction as a Baker Scholar, his M.Sc. in Medical Genetics and Microbiology from the University of Toronto, and his B.S. in Psychology from McGill University.

James J. MacDonald is a co-founder of Sana and has served as our Executive Vice President, General Counsel, and Corporate Secretary since September 2018. Prior to Sana, Mr. MacDonald served as Senior Vice President and Chief Intellectual Property Officer at Juno from March 2014 to May 2018, where he was responsible for all worldwide intellectual property activities, including strategy, development, transactions, litigation, and counseling. From March 2009 to March 2014, Mr. MacDonald held both legal and business roles at Tessera, Inc. and Tessera Intellectual Property Corp. (subsidiaries of Xperi Corporation) (collectively, Tessera), both of which are semiconductor technology companies, and most recently served as Executive Vice President of Intellectual Property & Business Development, where he was responsible for business development, licensing, and litigation. Prior to Tessera, Mr. MacDonald held senior roles at BigBand Networks, Inc. (later acquired by ARRIS Group), a provider of platforms for broadband multimedia services, and Tumbleweed Communications Corp. (later acquired by Axway Inc.), a secure internet communication solutions company, practiced law at Wilson Sonsini Goodrich & Rosati PC, and was a research and development engineer at Procter & Gamble. Mr. MacDonald received his J.D. from Vanderbilt University Law School and his B.S. in Chemical Engineering from Stanford University.

Corporate Governance

Board of Directors

Our Board oversees our business and monitors the performance of our management. In accordance with our corporate governance procedures, our Board does not involve itself in our day-to-day operations. Our executive officers and management are responsible for the conduct and oversight of our day-to-day operations. Our directors fulfill their duties and responsibilities by preparing for, attending, and actively participating in meetings of our Board, which are held from time to time, and the respective committees of our Board on which they serve, including by reviewing relevant materials provided in advance of each meeting and making themselves available to management in between Board and committee meetings as needed. The independent directors meet in executive sessions without management or any non-independent directors at least quarterly. The purpose of these executive sessions is to promote open and candid discussion among our independent directors.

During the year ended December 31, 2021, our Board held seven meetings, our audit committee held five meetings, our compensation committee held six meetings, and our nominating and corporate governance committee held two meetings. Each incumbent director attended at least 75% of the total meetings of (i) our Board held during the period for which he or she has been a director and (ii) the committee(s) on which that particular director served during the period for which he or she has been a member of such committee(s), except that Mr. Bishop did not attend 75% of the meetings of the audit committee, Mr. Nelsen did not attend 75% of the meetings of the compensation committee during the time on which he served on the compensation committee, and Dr. Bilenker did not attend 75% of the meetings of the nominating and corporate governance committee.

We encourage our directors to attend each annual meeting of stockholders. We did not hold an annual meeting of stockholders during 2021. We expect each of our directors will attend the Annual Meeting.

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Board of Directors Independence

Rule 5605 of the Nasdaq Listing Rules requires that independent directors comprise a majority of a listed company’s board of directors. In addition, the Nasdaq Listing Rules require that, subject to specified exceptions, each member of a listed company’s audit, compensation, and nominating and corporate governance committees be independent, that audit committee members also satisfy independence criteria set forth in Rule 10A-3 under the Exchange Act, and that compensation committee members also satisfy independence criteria set forth in Rule 10C-1 under the Exchange Act and Nasdaq Listing Rule 5605(d)(2). Under Nasdaq Listing Rule 5605(a)(2), a director will only qualify as an “independent director” if, in the opinion of a listed company’s board of directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director. In order to be considered independent for purposes of Rule 10A-3 under the Exchange Act, a member of an audit committee of a listed company may not, other than in his or her capacity as a member of such audit committee, the board of directors, or any other board committee: (i) accept, directly or indirectly, any consulting, advisory, or other compensatory fee from the company or any of its subsidiaries; or (ii) be an affiliated person of the company or any of its subsidiaries. Pursuant to Rule 10C-1 under the Exchange Act and Nasdaq Listing Rule 5605(d)(2), in affirmatively determining the independence of a member of a compensation committee of a listed company, the board of directors must consider all factors specifically relevant to determining whether that member has a relationship with the company that is material to that member’s ability to be independent from management in connection with the duties of a compensation committee member, including: (a) the source of compensation of such member, including any consulting, advisory, or other compensatory fee paid by the company to such member; and (b) whether such member is affiliated with the company, a subsidiary of the company, or an affiliate of a subsidiary of the company.

Our Board undertook a review of the composition of our Board and its committees and the independence of each director that has served on our Board since, or that served on our Board during, 2021. In reviewing the independence of our directors, our Board considered the relationships that each non-employee director has with our company and all other facts and circumstances our Board deemed relevant in determining independence, including the beneficial ownership of our capital stock by each non-employee director. Based upon information requested from and provided by each director concerning his or her background, employment, and affiliations, including family and other relationships, including those relationships described under the section of this proxy statement titled “Transactions with Related Persons,” our Board affirmatively determined that all of our current directors, with the exception of Drs. Harr and Mulligan, satisfy general independence requirements under the Nasdaq Listing Rules. Our Board also determined that Dr. von Maltzahn satisfied general independence requirements under the Nasdaq Listing Rules during the period in which he served as a director. Our Board also determined that Drs. Harr and Mulligan did not satisfy general independence requirements under the Nasdaq Listing Rules. In making these determinations, our Board found that none of our current directors, other than Drs. Harr and Mulligan, had a material or other disqualifying relationship that would interfere with their exercise of independent judgment in carrying out their responsibilities as a director, and that each director, other than Drs. Harr and Mulligan, is “independent” as that term is defined under Rule 5605(a)(2) of the Nasdaq Listing Rules. Dr. Harr, our President and Chief Executive Officer, and Dr. Mulligan, our Executive Vice Chairman and Head of SanaX, respectively, are not independent directors by virtue of their employment with us. Our Board also determined that each current and former member of our audit, compensation, and nominating and corporate governance committees satisfied the independence standards for such committees established by the SEC and the Nasdaq Listing Rules, as applicable, during the periods in which they served on such committees.

Committees of the Board of Directors

Our Board has three standing committees: an audit committee, a compensation committee, and a nominating and corporate governance committee.

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The following table provides membership and meeting information for the year ended December 31, 2021 for each committee.

Below is a description of each committee of our Board.

Audit Committee

Mr. Bishop and Mses. Seitz and Wilderotter serve as members of our audit committee. Ms. Wilderotter served as the chairperson of our audit committee until June 23, 2021, when Ms. Seitz was appointed as the chairperson. Our Board has determined that each member of our audit committee is an independent director under the corporate governance standards of the Nasdaq Listing Rules and the independence requirements of Rule 10A-3 under the Exchange Act. In addition, our Board has determined that each member of our audit committee is financially literate and that each of Mses. Seitz and Wilderotter qualifies as an “audit committee financial expert,” as such term is defined in Item 407(d)(5) of Regulation S-K. In making this determination, our Board considered each of Mses. Seitz’ and Wilderotter’s formal education and the nature and scope of each of their professional experience, as further described in the section of this proxy statement titled “Information About Our Board of Directors,” and, with respect to Ms. Wilderotter, her experience serving on public company audit committees. This designation does not impose on such directors any duties, obligations, or liabilities that are greater than those generally imposed on members of our audit committee and our Board.

Our audit committee is directly responsible for, among other things:

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Our audit committee operates under a written charter that satisfies the applicable standards of the SEC and the Nasdaq Listing Rules, which is available in the “Corporate Governance” section of our investor relations website at ir.sana.com/corporate-governance/governance-overview. The inclusion of our website address here and elsewhere in this proxy statement does not include or incorporate by reference the information on our website into this proxy statement.

Audit Committee Report⁽¹⁾

The primary purpose of the audit committee is to oversee the company’s financial reporting processes on behalf of the company’s Board of Directors and stockholders. The audit committee’s functions are more fully described in its charter, which is available at the company’s investor relations website at ir.sana.com/corporate-governance/governance-overview. Management has the primary responsibility for preparation of the company’s financial statements and reporting processes, including the company’s systems of internal controls. The company’s independent registered public accounting firm is responsible for performing an independent audit of the company’s financial statements in accordance with generally accepted auditing standards and issuing a report thereon. In fulfilling its oversight responsibilities, the audit committee has reviewed and discussed the audited financial statements for the fiscal year ended December 31, 2021 with management and the company’s independent registered public accounting firm, Ernst & Young LLP (EY).

The audit committee has discussed with EY the matters required to be discussed by the applicable requirements of the Public Company Accounting Oversight Board (PCAOB) and the SEC. The audit committee has also received the written disclosures and the letter from EY required by applicable requirements of the PCAOB regarding EY’s communications with the audit committee concerning independence and has discussed with EY its independence. The audit committee has also considered whether EY’s provision of non-audit services to the company is compatible with its independence and concluded that EY is independent from the company and its management.

Based on the foregoing, the audit committee recommended to the Board that the company’s audited financial statements be included in the company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2021 for filing with the SEC.

Sana Biotechnology, Inc. Audit Committee

Michelle Seitz, CFA, Chairperson²

Hans E. Bishop

Mary Agnes (Maggie) Wilderotter²

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Compensation Committee

During 2021, each of Messrs. Bishop and Nelsen and Drs. Cole and Reicin served on our compensation committee. Until April 2021, our compensation committee consisted of Messrs. Bishop and Nelsen and Dr. Cole, with Mr. Bishop serving as the chairperson. In April 2021, Mr. Nelsen resigned from his position as a member of our compensation committee, and Dr. Reicin was appointed as a member our compensation committee. Thereafter, our compensation committee has consisted of Mr. Bishop and Drs. Cole and Reicin, with Mr. Bishop serving as the chairperson. Each member of our compensation committee is, or was during the period in which he or she served, a non-employee director within the meaning of Rule 16b-3 under the Exchange Act and each is, or was during the period in which he or she served, an independent director under the corporate governance standards of the Nasdaq Listing Rules and the independence requirements of Rule 10C-1 under the Exchange Act.

Our compensation committee is responsible for, among other things:

Our compensation committee operates under a written charter that satisfies the applicable standards of the SEC and the Nasdaq Listing Rules, which is available in the “Corporate Governance” section of our investor relations website at ir.sana.com/corporate-governance/governance-overview.

Our compensation committee periodically reviews and evaluates the components and effectiveness of our executive compensation program to ensure that it is consistent with our goals and aligned with our executive compensation peer group and the marketplace in which we compete for executive talent. In conducting these reviews and evaluations, our compensation committee utilizes the services of Aon’s Human Capital Solutions practice, a division of Aon plc (Aon), a national executive compensation consulting firm, as an independent compensation consultant to provide advice regarding executive compensation, including with respect to the composition of our peer group, gather peer group and other relevant executive compensation information and trends, and analyze this information.

Pursuant to its charter, our compensation committee has the sole authority to retain compensation consultants to assist in its evaluation of executive and director compensation. Our compensation committee utilizes information, including peer data, regarding the compensation of our directors and executive officers provided by Aon in evaluating, recommending, and determining compensation levels. Our compensation committee has determined that Aon is independent under the Nasdaq Listing Rules. Our compensation committee also has authority to engage legal counsel and other consultants, accountants, experts, and advisors as it deems appropriate to carry out its responsibilities.

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Compensation Committee Interlocks and Insider Participation

None of the members of our compensation committee has ever been an officer or employee of the company, including during the fiscal year ended December 31, 2021. None of our executive officers serves, or has served during the last three years, as a member of the board of directors, compensation committee, or other board committee performing equivalent functions of any entity that has one or more of its executive officers serving as one of our directors or as a member of our compensation committee.

Nominating and Corporate Governance Committee

Drs. Bilenker and Yang and Ms. Wilderotter serve as members of our nominating and corporate governance committee, with Ms. Wilderotter serving as the chairperson. Each member of our nominating and corporate governance committee is an independent director under the corporate governance standards of the Nasdaq Listing Rules.

Our nominating and corporate governance committee is responsible for, among other things:

Our nominating and corporate governance committee operates under a written charter that satisfies the applicable standards of the Nasdaq Listing Rules, which is available in the “Corporate Governance” section of our investor relations website at ir.sana.com/corporate-governance/governance-overview.

It is the policy of our nominating and corporate governance committee to select nominees for director that ensure that our Board as a whole collectively possesses a broad range of skills, expertise, and business, industry, and other knowledge and experience that will enhance Board effectiveness and strengthen our Board’s ability to carry out its oversight role on behalf of stockholders. Though we do not have a specific policy with respect to Board diversity, our nominating and corporate governance committee considers diversity as one of many relevant factors in evaluating potential directors. Our nominating and corporate governance committee considers diversity broadly and may consider the following criteria, among others that our nominating and corporate governance committee deems appropriate, when considering candidates for our Board: (i) diversity of personal background, perspective, and experience; (ii) personal and professional integrity, strong ethics, and values; (iii) practical and mature business judgment; (iv) experience in corporate management, such as serving as an officer of a publicly held company; (v) experience as a board member of another publicly traded company; (vi) professional and academic experience relevant to our industry; (vii) leadership skills; (viii) experience in finance and accounting and/or executive compensation practices; and (viii) diversity of business or career experience relevant to our success. In addition, our nominating and corporate governance committee will consider whether the nominee has the time required for preparation, participation, and attendance at Board and committee meetings, and whether there are potential conflicts of interest with the nominee’s other personal and professional pursuits.

In the case of any incumbent director whose term of office is set to expire, the nominating and corporate governance committee reviews such director’s overall service to the company during his or her term, including such director’s level of participation, contributions to the Board, and quality of performance, as well as any relationships or transactions that might impair such director’s independence and any other factors that might otherwise affect such director’s ability to carry out his or her responsibilities as a director.

In the case of a new director candidate, the nominating and corporate governance committee also determines whether the nominee is independent for Nasdaq purposes, which determination is based upon applicable Nasdaq Listing Rules, applicable SEC rules and regulations, and the advice of counsel, if necessary. The nominating and

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corporate governance committee often uses its network of contacts to compile a list of potential candidates and may also engage a professional search firm to identify and screen additional candidates and coordinate and advise on candidate search and selection efforts. The nominating and corporate governance committee also considers the results of the Board’s most recent self-evaluation to assess and determine the needs of the Board. The nominating and corporate governance committee evaluates the background and qualifications of candidates, conducts interviews of selected candidates, and then selects and recommends nominees to the full Board for review and approval.

In accordance with our bylaws and the charter of our nominating and corporate governance committee, nominations and recommendations of individuals for election to our Board at an annual meeting of stockholders may be made by any stockholder of record entitled to vote for the election of directors at such meeting who provides timely notice in writing to our Corporate Secretary at our principal executive offices. See the section above titled “General Information” for additional information on the requirements for stockholder proposals.

Director nominees identified and submitted by stockholders are analyzed by our nominating and corporate governance committee in the same manner as nominees identified by our nominating and corporate governance committee. If our nominating and corporate governance committee believes a candidate would be a valuable addition to our Board, it will recommend that candidate’s election to the full Board.

Given that our Board members can provide valuable perspectives and leadership across different areas, our nominating and corporate governance committee periodically reviews the membership of the Board’s committees and, if and when appropriate, makes recommendations to the Board to reconstitute the membership of its committees and to rotate which member of the Board serves as chairperson of each committee.

Board Diversity Matrix

Below is the composition of our current Board with respect to certain diversity characteristics as of April 26, 2022.

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Board Leadership Structure

Our amended and restated bylaws and corporate governance guidelines provide our Board with flexibility to combine or separate the positions of Chief Executive Officer and Chairman of the Board. Dr. Harr currently serves as President and Chief Executive Officer while Mr. Bishop serves as Chairman of the Board. We believe that separation of these positions is appropriate at this time and reinforces the independence of the Board from management, creates an environment that encourages objective oversight of management’s performance, and enhances the effectiveness of our Board as a whole. However, our Board continues to periodically evaluate our leadership structure and may choose in the future to combine the positions of Chief Executive Officer and Chairman of the Board as it deems appropriate based on the best interests of the company and its stockholders.

As our current Chairman of the Board, Mr. Bishop presides over meetings of our Board and holds such other powers and carries out such other duties as are customarily carried out by the chairperson of the board of directors of a public company.

Our independent directors meet regularly in executive sessions without management to consider such matters as they deem appropriate. The Chairman of the Board may call additional executive sessions of the independent directors at any time, and the Chairman of the Board must call an executive session at the request of a majority of the independent directors. The purpose of these executive sessions is to promote open and candid discussion among our independent directors.

Role of the Board in Risk Oversight

Risk is inherent with every business, and how well a business manages risk can ultimately determine its success. We face a number of risks. Our Board believes that risk assessment, oversight, and management is an important part of establishing, updating, and executing our business strategy and encourages management to promote a culture that incorporates risk management into our corporate strategy and day-to-day business operations. Our Board, as a whole and at the committee level, has oversight responsibility relating to risks that could affect our corporate strategy, business objectives, compliance, operations, financial condition, and performance. Our Board focuses its oversight on the most significant risks facing the company and on the company’s processes to identify, prioritize, assess, manage, and mitigate those risks. Our Board and its committees receive regular reports from members of our senior management on areas of material risk to us, including strategic, operational, financial, legal, and regulatory risks. While our Board has an oversight role, management is principally tasked with direct responsibility for management and assessment of risks and the implementation of processes and controls to mitigate their effects on the company. As part of executing on these responsibilities, management discusses strategic and operational risks at regular management meetings and conducts specific strategic planning and review sessions during the year that include a focused discussion and analysis of the risks facing our company.

Our Board does not have a standing risk management committee, but rather administers this risk management function directly through our Board as a whole, as well as through its standing committees that address risks inherent in their respective areas of oversight.

Our audit committee, as part of its responsibilities, oversees the management of financial risks, including accounting matters, liquidity and credit risks, corporate tax positions, insurance coverage, and cash investment strategies and results, and steps our management has taken to monitor and control these risks. In addition, our audit committee reviews and approves or disapproves any related-person transactions. Our audit committee is also responsible for overseeing the management of risks relating to the performance of our internal audit function and our independent registered public accounting firm, risks related to cybersecurity, and our systems of internal controls and disclosure controls and procedures. For example, relevant members of management periodically report to our audit committee regarding cybersecurity risks and related policies and initiatives that the company has implemented to address such risks. In addition, Ms. Wilderotter, a member of our audit committee, has expertise with respect to cybersecurity matters, as described above in the section titled “Information About Our

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Board of Directors.” Additionally, pursuant to its charter, the audit committee may retain, as necessary, subject matter experts and advisers to assist in its oversight of risk management within the company, including with respect to cybersecurity risk.

Our compensation committee is responsible for overseeing the management of risks relating to our executive compensation and overall compensation and benefit strategies, plans, arrangements, practices, and policies, including whether any of the foregoing have the potential to encourage excessive risk-taking.

Our nominating and corporate governance committee oversees the management of risks associated with our overall corporate governance practices and the independence and composition of our Board, including the effectiveness of our corporate governance guidelines. Each committee of our Board provides regular reports to the full Board. Our Board may also create additional committees in the future to assist in risk oversight. Our corporate governance guidelines are available on our website at ir.sana.com/corporate-governance/governance-overview.

Code of Business Conduct and Ethics

We have adopted a code of business conduct and ethics (our code of conduct) that applies to all our directors, officers, and employees, including those officers responsible for financial reporting. The code of conduct is available on our website at ir.sana.com/corporate-governance/governance-overview.

We intend to satisfy the disclosure requirement under Item 5.05 of Form 8-K regarding future amendments to, or waivers from, any provision of our code of conduct that applies to our principal executive officer, principal financial officer, principal accounting officer, or controller, or persons performing similar functions, by posting such information on our website at the Internet address set forth above.

Hedging and Pledging Policies

Our insider trading compliance policy expressly prohibits each of our directors, officers, and employees from engaging in any speculative transaction designed to decrease the risks associated with holding our securities, including hedging or similar transactions. We also prohibit any pledging of our securities as collateral for loans and the holding of our securities in margin accounts. An exception from such policies must be approved by our General Counsel, who serves as our compliance officer.

Section 16(a) Reports

The section of this proxy statement titled “Section 16(a) Beneficial Ownership Reporting Compliance” is incorporated by reference into this section.

Stockholder Communications with Our Board of Directors

Stockholders wishing to communicate with our Board or specific individual directors may send correspondence to our Corporate Secretary, c/o Sana Biotechnology, Inc., 188 East Blaine Street, Suite 400, Seattle, Washington 98102. Our Corporate Secretary reviews all communications and forwards them to the intended recipient(s) consistent with a screening policy, which provides that sales materials, routine items, and items unrelated to the duties and responsibilities of the Board are not relayed to directors.

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EXECUTIVE COMPENSATION

As described above, we are an emerging growth company under applicable federal securities laws and are, therefore, permitted to conform with certain reduced public company reporting requirements, including the compensation disclosures required of a “smaller reporting company,” as that term is defined in Rule 12b-2 under the Exchange Act. The following compensation disclosure is intended to comply with the compensation disclosure requirements applicable to smaller reporting companies.

This section discusses the material components of our executive compensation program for each individual who served as our principal executive officer at any time during the year ended December 31, 2021 and our next two most highly compensated executive officers in respect of their service to our company for the year ended December 31, 2021. We refer to these individuals as our named executive officers. Our named executive officers for the year ended December 31, 2021 are as follows:

Executive Compensation Philosophy

We have a pay-for-performance focused executive compensation philosophy. We believe that compensation should be designed to drive company performance to increase stockholder value. We seek to achieve this by using different elements of compensation and a market-based approach to attract, retain, and motivate a high-performing team of executive officers and by aligning a majority of the compensation of each of our executives with the company’s short- and long-term performance. We believe that it is important that performance- and equity-based compensation comprise a substantial portion of the total compensation of each of our executives in order to align our executives’ interests with those of our stockholders.

In addition, we believe that our success depends in part on the commitment of our executive officers to our culture and our core values, as described below. Accordingly, as part of the assessment of each executive officer’s individual performance, when applicable, in addition to considering the achievement of individual research, development, financial, corporate, and operational goals, our Board and compensation committee also consider such executive officer’s compliance with our corporate policies and commitment to and demonstration of our culture and core values.

Our Culture and Core Values

We are committed to our mission of creating and delivering engineered cells as medicines to impact the lives of patients. Our core values – to lead from every seat, thrive as a team, and make it happen – are key to our culture and are described in greater detail below. We believe that our core values are what ground us, keep our team connected, and make it possible to do our best work.

In addition, we believe that a diverse workforce strengthens us as a company and a community, which is essential for us to meaningfully change outcomes for patients across a wide range of diseases. We strive to foster an inclusive environment that attracts diverse talent and enables all people to thrive.

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Summary Compensation Table

The following table shows information regarding the compensation of our named executive officers during the fiscal years ended December 31, 2021 and, as to Dr. Harr only, 2020. Information regarding the compensation paid to Dr. Agarwal and Mr. Hardy during the year ended December 31, 2020 is not set forth below as they were not named executive officers for that year.

Narrative Disclosure to Summary Compensation Table

Executive Compensation Elements

The primary elements of our executive compensation program for 2021 were:

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In addition to these primary elements of executive compensation, we also offer our executive officers broad-based health and welfare benefits and 401(k) plan benefits consistent with the benefits we provide to our other full-time, salaried employees.

Base Salary

The purpose of base salary compensation is to provide each executive with a competitive level of fixed cash compensation that is paid regularly throughout the year. The amount of base salary we pay each executive is determined by our compensation committee primarily based upon the range of salaries for similar positions at peer companies and takes into consideration the executive officer’s skillset, experience, role, responsibilities, performance, and contributions to the company. Base salary is the only element of compensation that is fixed; the remainder of each executive officer’s potential compensation is composed of variable compensation that is designed to incentivize shorter-term (annual) or longer-term performance of the company.

Our compensation committee reviewed and evaluated the base salaries of our executive officers and approved the 2021 base salaries of $625,000, $514,537, and $425,000, respectively, for each of Dr. Harr, Dr. Agarwal, and Mr. Hardy.

Annual Performance-Based Cash Compensation

We maintain a Bonus Plan, pursuant to which each of our named executive officers was eligible in 2021 to earn annual cash bonuses based on the achievement of certain corporate performance objectives approved by our Board and our compensation committee, as well as individual performance for Dr. Agarwal and Mr. Hardy. Dr. Harr’s annual cash bonus is determined solely based on certain corporate performance objectives. Each named executive officer’s target bonus amount under the Bonus Plan is determined as a percentage of his or her annual base salary. The target bonus percentage for 2021 for each of Dr. Harr, Dr. Agarwal, and Mr. Hardy was 60%, 40%, and 40%, respectively.

In February 2022, our Board and compensation committee approved the achievement of our 2021 corporate goals at 100%. Based on this level of achievement, and, in the case of Dr. Agarwal and Mr. Hardy, adjustments for the individual performance during 2021, (i) our Board approved the 2021 cash incentive payment to Dr. Harr, and (ii) our compensation committee approved the 2021 cash incentive payments to Dr. Agarwal and Mr. Hardy, in each case, in the amounts shown in the Summary Compensation Table above.

Long-Term Equity Incentive Awards

Although we do not have a formal policy with respect to the grant of equity incentive awards to our executive officers, or any formal equity ownership guidelines applicable to them, we believe that equity grants provide our executive officers with a strong link to our long-term performance, create an ownership culture, and help align the interests of our executive officers and our stockholders. In addition, we believe that equity grants with a time-based vesting feature promote executive retention because this feature incentivizes our executive officers to remain in our employment during the vesting period. Accordingly, our Board periodically reviews the equity incentive compensation of our executives, including our named executive officers, and from time to time may grant equity incentive awards to them in the form of stock options, restricted stock awards, or restricted stock units.

We typically grant equity awards to each executive officer at the start of employment as well as on an annual basis, based on individual performance, to promote retention and to provide our executive officers with continued incentive to improve corporate performance and execute our strategic objectives. These equity awards generally vest over several years to focus our executives on the company’s success over a multi-year period and promote the retention of our executive officers.

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We did not grant annual equity awards to most of our employees, including our executive officers, in 2021 as we elected to make such grants in November 2020 due to our planned IPO, which we executed in February 2021. Accordingly, Dr. Harr and Mr. Hardy received annual equity awards in November 2020. Such equity awards comprised stock option awards that vested with respect to 25% of the shares subject to each option on February 15, 2022, and vest with respect to 1/48 of the shares subject to each option each month thereafter, subject to the applicable executive’s continuous service to the company through each applicable vest date. Dr. Agarwal did not receive an annual equity award in November 2020. Accordingly, in February 2021, our compensation committee approved the grant to Dr. Agarwal of an annual equity award comprising an option to purchase 76,682 shares of our common stock. This stock option award vested with respect to 25% of the shares subject to the option on February 15, 2022, and vests with respect to 1/48 of the shares subject to the option each month thereafter, subject to Dr. Agarwal’s continuous service to the company through each applicable vest date. We resumed making annual equity awards to our employees, including our executive officers, in February 2022 and expect to continue to grant annual equity awards going forward.

One-Time Discretionary Bonus Compensation

In connection with our IPO, our named executive officers were awarded one-time discretionary cash bonuses in the amounts shown in the Summary Compensation Table above to reward our named executive officers for their contributions to the successful consummation of our IPO. The bonus awarded to Dr. Harr was approved by our Board, and the bonuses awarded to Dr. Agarwal and Mr. Hardy were approved by our compensation committee. These bonus payments were in addition to any bonus our named executive officers earned with respect to their respective performance under our Bonus Plan.

Severance and Change in Control Benefits

We believe that offering reasonable and competitive severance benefits, including in connection with a change in control of the company, as part of an overall compensation package is necessary to effectively compete for, attract, and retain executive talent. We have agreed to provide certain severance benefits to our named executive officers pursuant to our offer letter agreements with our named executive officers, as described below in the section titled “Employment Arrangements,” and pursuant to our Change in Control Severance Plan (Severance Plan), as described below.

The severance benefits provided under our Severance Plan do not supersede any severance benefits provided to our named executive officers pursuant to their offer letter agreements, and to the extent that a named executive officer’s offer letter agreement provides for severance benefits that are more advantageous to such named executive officer than our Severance Plan, such named executive officer will continue to be entitled to the severance benefits provided for in his offer letter agreement. If, however, the Severance Plan provides for severance benefits that are more advantageous to such named executive officer than his offer letter agreement, then such named executive officer will be entitled to the severance benefits provided for in our Severance Plan, provided that the value of the severance benefits that such named executive officer will be entitled to under the Severance Plan will be reduced by the value of the severance benefits to which such executive officer is entitled under his offer letter agreement.

Change in Control Severance Plan

Each of Dr. Agarwal and Mr. Hardy is eligible to participate in our Severance Plan, which our Board adopted in December 2018. Under the Severance Plan, in the event the applicable executive officer’s employment is terminated by us without “cause” or such executive officer resigns for “good reason” (each such term as defined below) during the period commencing three months prior to a change in control and ending 12 months after a change in control of the company, such executive officer is entitled to receive (i) an amount equal to the sum of 12 months’ base salary and 100% of such executive’s target annual bonus, in each case, as in effect at the time of termination, payable in installments over the 12-month period following the termination date in accordance with

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our standard payroll policies, (ii) reimbursement for continued health, vision, and dental coverage through COBRA for such executive officer and such executive officer’s spouse and dependents for a period of up to 12 months, and (iii) accelerated vesting of all equity awards held by such executive officer.

For purposes of our Severance Plan, the following terms have the following meanings:

The Severance Plan requires as a condition to receiving severance benefits that, among other things, the executive officer execute and not revoke a general release of claims against us to mitigate any potential liability or dispute or the initiation of any litigation with the departing executive officer and also that the departing executive officer comply with the confidentiality agreement and any other agreement between us and such departing executive officer following the termination of such executive officer’s employment.

Other Benefits

All of our named executive officers are eligible to participate in our employee benefit plans, including our 401(k) plan, our medical, dental, vision, short- and long-term disability, and group life insurance plans, and participate

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in our ESPP (as defined below in the section titled “Executive Compensation – Equity Benefit Plans – 2021 Employee Stock Purchase Plan”), in each case on the same basis as our other employees, including, effective January 1, 2022, the matching contributions provided under our 401(k) plan. Our 401(k) plan provides that each participant may contribute up to 100% of his or her pre-tax compensation, up to a statutory limit of $19,500 in 2021 and $20,500 in 2022. Participants who are at least 50 years old can also make “catch-up” contributions of an additional $6,500 above the statutory limit in 2021 and an additional $6,500 above the statutory limit in 2022. Effective January 1, 2022, we provide a company match equal to 100% of the amount contributed by an employee, up to a maximum amount of $4,000 per year, and we pay all company matches in cash. We began paying the company match amounts payable in 2022 to our employees, including our named executive officers, as of April 1, 2022, and included a true-up of any amounts that would have otherwise been paid as a company match from January 1 through March 31, 2022. Our 401(k) plan also permits us to make discretionary contributions, subject to established limits and a vesting schedule. To date, we have not made any discretionary contributions to the plan on behalf of participating employees. Our compensation committee periodically reviews the levels of benefits provided to our executive officers to ensure they remain reasonable and consistent with its compensation philosophy.

Perquisites

We do not as a general practice provide perquisites or other personal benefits to our executive officers that differ materially from those available to employees generally.

No Tax Gross-Ups

We do not make gross-up payments to cover our named executive officers’ personal income taxes that may pertain to any of the compensation or perquisites paid or provided by us.

Employment Arrangements

We have entered into employment offer letter agreements with each of our named executive officers. Each of the offer letters with our named executive officers provides for “at will” employment and sets forth the initial compensation arrangements for the executive officer, including with respect to the executive officer’s initial base salary, annual target cash bonus opportunity, and new hire equity awards (each of which is disclosed in more detail in the table below titled “Outstanding Equity Awards at Fiscal Year-End,” to the extent it was not exercised by the applicable executive officer (with respect to option awards) or vested (with respect to restricted stock awards) as of December 31, 2021). The terms and conditions of each offer letter agreement, except for Dr. Harr’s offer letter, were negotiated by Dr. Harr and were approved by either our Board or compensation committee. Dr. Harr’s offer letter was negotiated and approved by our compensation committee.

Dr. Harr’s Offer Letter

On September 27, 2018, we entered into an offer letter with Dr. Harr providing for at will employment, an annual base salary, eligibility to earn an annual cash bonus, and eligibility to participate in our employee benefit plans.

Under Dr. Harr’s offer letter, upon a termination without “cause” or resignation for “good reason” (each such term as defined below), other than during the period commencing three months prior to a change in control and ending 12 months after a change in control of the company, Dr. Harr is entitled to receive (i) an amount equal to the sum of 12 months’ base salary and 100% of his target annual bonus, in each case, as in effect at the time of termination, payable in installments over the 12-month period following the termination date in accordance with our standard payroll policies, and (ii) payment or reimbursement for continued health, vision, and dental coverage through COBRA for Dr. Harr, his spouse, and any applicable dependents for a period of up to 12 months, in each case, subject to, among other things, Dr. Harr providing a general release of claims against us. On the day of any such termination or resignation, we may enter into a consulting agreement with Dr. Harr for a

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period of 12 months that provides for (i) annual consulting fees equal to his annual base salary in effect at the time of the termination or resignation, (ii) accelerated vesting of equity awards held by him that would have vested had he remained employed for a period of 12 months following his termination date, and (iii) his right to exercise any vested stock options held by him for a period of up to 90 days following the termination or expiration of the consulting agreement.

In the event Dr. Harr’s employment is terminated by us without cause or he resigns for good reason during the period commencing three months prior to a change in control and ending 12 months after a change in control of the company, Dr. Harr is entitled to receive (i) an amount equal to the sum of 18 months’ base salary and 150% of his target annual bonus, in each case, as in effect at the time of termination, payable in a single cash lump sum, (ii) payment or reimbursement for continued health, vision, and dental coverage through COBRA for Dr. Harr, his spouse, and any applicable dependents for a period of up to 18 months, (iii) accelerated vesting of all equity awards held by him, and (iv) his right to exercise any vested stock options held by him (after giving effect to any accelerated vesting providing in connection with his termination) for a period of up to 90 days following his termination of employment, in each case, subject to, among other things, Dr. Harr providing a general release of claims against us.

If Dr. Harr is terminated by the company other than for cause or if Dr. Harr resigns for good reason, he will be entitled to any unpaid annual bonus for the year prior to the year of termination and a pro rata annual bonus for the year of termination, in each case, to be paid when such annual bonuses are paid to employees generally. In addition, if Dr. Harr is terminated due to his death, his estate or beneficiary will be entitled to any unpaid annual bonus for the year prior to the year of termination and a pro rata annual bonus for the year of termination, in each case, to be paid as soon as administratively practicable following the date of such termination.

For purposes of Dr. Harr’s offer letter, the following terms have the following meanings:

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Dr. Agarwal’s Offer Letter

On May 20, 2019, we entered into an offer letter with Dr. Agarwal providing for at will employment, an annual base salary, eligibility to earn an annual cash bonus, and eligibility to participate in our employee benefit plans.

Under Dr. Agarwal’s offer letter, upon Dr. Agarwal’s termination of employment by us other than for “cause” or his resignation for “good reason” (each such term as defined below), other than during the period commencing three months prior to a change in control and ending 12 months after a change in control of the company, he is entitled to receive (i) an amount equal to the sum of nine months’ base salary and 75% of his target annual bonus, in each case, as in effect at the time of termination, payable in installments over the nine-month period following the termination date in accordance with our standard payroll policies, and (ii) payment or reimbursement for continued health, vision, and dental coverage through COBRA for Dr. Agarwal, his spouse, and any applicable dependents for a period of up to nine months, in each case, subject to, among other things, Dr. Agarwal providing a general release of claims against us. On the day of any such termination or resignation, we may enter into a consulting agreement with Dr. Agarwal for a period of nine months that provides for (i) annual consulting fees equal to his annual base salary in effect at the time of the termination or resignation, (ii) accelerated vesting of equity awards held by him that would have vested had he remained employed for a period of nine months following his termination date, and (iii) the right to exercise any vested stock options held by him for a period of up to 90 days following the term of the consulting agreement.

In the event Dr. Agarwal’s employment is terminated by us without cause or he resigns for good reason during the period commencing three months prior to a change in control and ending 12 months after a change in control of the company, Dr. Agarwal is entitled to receive (i) an amount equal to the sum of 12 months’ base salary and 100% of his target annual bonus, in each case, as in effect at the time of termination, payable in a single cash lump sum, (ii) payment or reimbursement for continued health, vision, and dental coverage through COBRA for Dr. Agarwal, his spouse, and any applicable dependents for a period of up to 12 months, (iii) accelerated vesting of all equity awards held by him, and (iv) his right to exercise any vested stock options held by him (after giving effect to any accelerated vesting providing in connection with his termination) for a period of up to 90 days following his termination of employment, in each case, subject to Dr. Agarwal providing a general release of claims against us.

For purposes of Dr. Agarwal’s and Mr. Hardy’s offer letters, the following terms have the following meanings:

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Mr. Hardy’s Offer Letter

On October 8, 2018, we entered into an offer letter with Mr. Hardy providing for at will employment, an annual base salary, eligibility to earn an annual cash bonus, and eligibility to participate in our employee benefit plans.

Under Mr. Hardy’s offer letter, upon Mr. Hardy’s termination of employment by us other than for “cause” or his resignation for “good reason”, other than during the period commencing three months prior to a change in control and ending 12 months after a change in control, he is entitled to receive (i) an amount equal to the sum of nine months’ base salary and 75% of his target annual bonus, in each case, as in effect at the time of termination, payable in installments over the nine-month period following the termination date in accordance with our standard payroll policies, and (ii) payment or reimbursement for continued health, vision, and dental coverage through COBRA for Mr. Hardy, his spouse, and any applicable dependents for a period of nine months, in each case, subject to, among other things, Mr. Hardy providing a general release of claims against us. On the day of any such termination or resignation, we may enter into a consulting agreement with Mr. Hardy for a period of nine months that provides for (i) annual consulting fees equal to his annual base salary in effect at the time of the termination or resignation, (ii) accelerated vesting of equity awards held by him that would have vested had he remained employed for a period of nine months following his termination date, and (iii) the right to exercise any vested stock options held by him for a period of up to 90 days following the term of the consulting agreement.

In the event Mr. Hardy’s employment is terminated by us without cause or he resigns for good reason during the period commencing three months prior to a change in control and ending 12 months after a change in control of the company, Mr. Hardy is entitled to receive (i) an amount equal to the sum of 12 months’ base salary and 100% of his target annual bonus, in each case, as in effect at the time of termination, payable in a single cash lump sum, (ii) payment or reimbursement for continued health, vision, and dental coverage through COBRA for Mr. Hardy, his spouse, and any applicable dependents for a period of up to 12 months, (iii) accelerated vesting of all equity awards held by him, and (iv) his right to exercise any vested stock options held by him (after giving effect to any accelerated vesting providing in connection with his termination) for a period of up to 90 days following his termination of employment, in each case, subject to Mr. Hardy providing a general release of claims against us.

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Compensation Risk Assessment

We believe that although a portion of the compensation provided to our executive officers and other employees is performance-based, our executive compensation program does not encourage excessive or unnecessary risk taking. This is primarily because our compensation programs are designed to encourage our executive officers and other employees to remain focused on both short-term and long-term strategic goals. As a result, we do not believe that our compensation programs are reasonably likely to have a material adverse effect on us.

Outstanding Equity Awards at Fiscal Year-End

The following table provides information regarding equity awards held by our named executive officers that were outstanding as of December 31, 2021.

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Equity Benefit Plans

2021 Incentive Award Plan, 2018 Equity Incentive Plan, and Restricted Stock Unit Plan

General. In January 2021, we adopted, and our stockholders approved, the 2021 Incentive Award Plan (the 2021 Plan), which became effective upon completion of our IPO. The purpose of the 2021 Plan is to attract and retain non-employee directors, executive officers, and other employees and service providers and to stimulate their efforts toward our continued success, long-term growth, and profitability. The 2021 Plan provides for the grant of a variety of stock-based compensation awards, including stock options, restricted stock awards, and restricted stock units. We also maintain the 2018 Equity Incentive Plan (the 2018 Plan), which we adopted in 2018 and was terminated in connection with our adoption of the 2021 Plan. No future awards will be granted under the 2018 Plan, but we have granted options and restricted stock awards that are outstanding thereunder. In addition, we maintain the Restricted Stock Unit Plan (the RSU Plan), which we adopted in March 2019 in connection with our acquisition of Cobalt Biomedicine, Inc. (Cobalt) to provide for awards of restricted stock units to certain employees and consultants, and under which we have granted restricted stock units that are outstanding. The outstanding options and restricted stock granted under the 2018 Plan and the outstanding restricted stock units granted under the RSU Plan will continue to be governed by the terms of the 2018 Plan or RSU Plan, as applicable.

Authorized Shares. As of April 8, 2022, we had 14,216,395 shares of common stock reserved for issuance pursuant to the 2021 Plan. On January 1 of every year, the number of shares of common stock available for issuance under the 2021 Plan automatically increases by the lesser of (i) 5% of the total number of outstanding shares of our common stock as of December 31 of the immediately preceding year, or (ii) such number of shares as may be determined by our Board or any authorized committee of our Board. On January 1, 2022, the total number of shares available for issuance under the 2021 Plan increased by 9,464,662 shares pursuant to this provision. The total number of shares of common stock available for issuance pursuant to restricted stock unit awards under the RSU Plan is 300,000 and is not subject to increase. As of December 31, 2021, options to purchase 3,999,107 shares of our common stock and 56,400 restricted stock units were outstanding under the 2021 Plan, options to purchase 12,920,860 shares of our common stock and 132,766 shares of restricted common stock were outstanding under the 2018 Plan, and 84,344 restricted stock units were outstanding under the RSU Plan.

Non-Plan Equity Issuances. In certain circumstances, including prior to the adoption of the 2018 Plan, our compensation committee has approved the issuance of options and restricted stock to certain employees separate from any equity plan of the company (collectively, the Non-Plan Issuances). As of December 31, 2021, the

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Non-Plan Issuances that remained outstanding consisted of 417,344 options to purchase shares of our common stock, 1,917,778 shares of restricted common stock, and 2,314,109 shares of restricted common stock purchased from the company and subject to vesting under the applicable stock purchase agreement.

2021 Employee Stock Purchase Plan

General. In January 2021, we adopted, and our stockholders approved, the 2021 Employee Stock Purchase Plan (the ESPP), which became effective upon completion of our IPO. The purpose of the ESPP is to enable our eligible employees, through payroll deductions or cash contributions, to purchase shares of our common stock, to increase our employees’ interest in our growth and success, and to encourage employees to remain in our employment. Under the ESPP, we may specify offerings with durations of not more than 27 months and may specify shorter purchase periods within each offering. The ESPP allows eligible employees to purchase shares of our common stock at a discount through payroll deductions of up to 15% of their earnings, subject to plan limitations. Unless otherwise determined by our Board, employees may purchase shares at 85% of the lower of the fair market value of our common stock on the first date of an offering or on the purchase date. Any of our employees may participate in the ESPP, except: (i) an employee whose customary employment is less than 20 hours per week; and (ii) an employee who, after exercising his or her rights to purchase common stock under the ESPP, would own shares of common stock (including shares that may be acquired under any outstanding options) representing 5% or more of the total combined voting power of all classes of our capital stock. An employee must be employed on the last trading day of the purchase period to acquire common stock under the ESPP.

Authorized Shares. As of April 8, 2022, we had 3,800,753 shares of common stock reserved for purchase by our eligible employees under the ESPP. The ESPP provides that on January 1 of every year, the number of shares of common stock available for purchase by our eligible employees automatically increases in an amount equal to the lesser of (i) 1% of the total number of outstanding shares of our common stock as of December 31 of the immediately preceding year or (ii) such number of shares as may be determined by our Board or any authorized committee of our Board. On January 1, 2022, the total number of shares available for issuance under the ESPP increased by 1,892,932 shares pursuant to this provision.

Indemnification

We entered into indemnification agreements with each of our directors and executive officers. These indemnification agreements and our certificate of incorporation and bylaws provide for indemnification of each of our directors and executive officers to the fullest extent permitted by Delaware law.

Our amended and restated certificate of incorporation also provides that, to the fullest extent permitted by law, we will indemnify any of our directors or officers against all damages, claims, and liabilities arising out of the fact that the person is or was our director or officer or served any other enterprise at our request as a director or officer. Amending this provision will not reduce our indemnification obligations relating to actions taken before any such amendment.

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DIRECTOR COMPENSATION

Cash and Equity Compensation

Prior to our IPO, our directors received equity grants in connection with their initial appointment or election to our Board, but did not receive compensation for their ongoing service on our Board. In connection with and effective upon completion of our IPO on February 3, 2021, we adopted our non-employee director compensation program (our Director Compensation Program). We subsequently updated our Director Compensation Program, effective each of December 8, 2021 and April 4, 2022, as further described below.

Effective February 3, 2021, under our Director Compensation Program, each non-employee director received an annual base cash retainer of $40,000. In addition, our non-employee directors received the following cash compensation for Board services, as applicable:

Effective December 8, 2021, we updated our Director Compensation Program to provide that any non-executive chairperson would instead receive an additional annual retainer of $35,000. No other changes were made to the annual retainer amounts under the Director Compensation Program as set forth above.

We pay all such amounts in quarterly installments. We also reimburse each director for his or her travel expenses incurred in connection with attendance at Board and committee meetings held in person, if any.

Each non-employee director may elect to receive all or part of his or her annual cash retainer in the form of restricted stock units under our 2021 Plan. Elections to convert all or a portion of the annual cash retainer into restricted stock units must generally be made on or prior to December 31 of the year prior to the year in which the annual cash retainer is scheduled to be paid, or such earlier deadline as may be established by our Board or compensation committee. Each individual who becomes a non-employee director is permitted to elect to convert the annual cash retainer payments scheduled to be paid in the same calendar year into restricted stock units, provided that the election is made prior to the date the individual becomes a non-employee director. Restricted stock units granted in lieu of all or a portion of the annual cash retainer are issued fully vested on the grant date and have a grant date fair value equal to the amount of the annual cash retainer or applicable portion thereof.

Additionally, if permitted by our Board or the compensation committee, non-employee directors may elect to defer all or part of the settlement of their restricted stock units issuable in lieu of all or a portion of the annual cash retainer. Any such deferral election is subject to the rules, conditions, and procedures as determined by our Board or the compensation committee in its sole discretion, which are intended to comply with the requirements of Section 409A of the Internal Revenue Code. Timing of the settlement of any deferred restricted stock units is made in accordance with the terms of the applicable deferral election.

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Under our Director Compensation Program, we grant to each non-employee director (i) an option to purchase that number of shares of our common stock calculated by dividing (a) $700,000 (for any directors who commenced their service prior to December 8, 2021) or $750,000 (for any directors who commence their service on or after December 8, 2021) by (b) the per share grant date fair value of the option, calculated based on the closing trading price of our common stock as of the grant date (or if the grant date is not a trading day, the immediately preceding trading day) and using assumptions published in our most recent periodic report as of the grant date, rounded down to the nearest whole share, upon the director’s initial appointment or election to our Board (the Initial Grant), and, effective April 4, 2022, up to a maximum of 115,000 options, and (ii) for each non-employee director who has served for at least four months as of the date of each annual meeting of stockholders, an option to purchase that number of shares of our common stock calculated by dividing (a) $350,000 (for any such grants made prior to December 8, 2021) or $425,000 (for any such grants made on or after December 8, 2021) by (b) the per share grant date fair value of the option, calculated based on the closing trading price of our common stock as of the grant date (or if the grant date is not a trading day, the immediately preceding trading day) and using assumptions published in our most recent periodic report as of the grant date, rounded down to the nearest whole share, on the date of each annual meeting of stockholders thereafter (the Annual Grant), and, effective April 4, 2022, up to a maximum of 65,000 options. The Initial Grant vests and becomes exercisable as to 1/36 of the underlying shares on a monthly basis over three years, subject to the director’s continued service to the company through each applicable vest date. The Annual Grant vests and becomes exercisable on the earlier of (i) the first anniversary of the grant date of such Annual Grant, or (ii) the day before the date of our next annual meeting of stockholders, subject to the director’s continued service to the company through such vest date.

In addition, in connection with our IPO, on February 3, 2021, our Board granted to each non-employee director an option to purchase that number of shares of our common stock calculated by dividing (a) $350,000 or $175,000 (depending on the applicable director’s tenure on our Board and other factors deemed relevant by our Board) by (b) the per share grant date fair value of the option, calculated based on the closing trading price of our common stock as of the grant date. The shares underlying these options vested in their entirety on February 3, 2022 with respect to each director who had provided continued service to the company through such date.

In the event of a change in control (as defined in the 2021 Plan) of the company, each Initial Grant and Annual Grant, along with any other stock options or equity-based awards held by any non-employee director, will vest and become exercisable immediately prior to such change in control.

Our compensation committee periodically reviews our Director Compensation Program, taking into account various factors, including the director compensation practices of our peer group, to determine whether any updates to this policy are appropriate.

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Director Compensation

The following table sets forth information concerning compensation accrued or paid to our non-employee directors during the year ended December 31, 2021 for their service on our Board. Drs. Harr and Mulligan are employees of the company and did not receive any compensation for their service as directors during 2021. Information regarding Dr. Harr’s compensation for 2021 is set forth in the Summary Compensation Table above and is not set forth in the table below.

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PROPOSAL 2

RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED

PUBLIC ACCOUNTING FIRM

General

Our audit committee has appointed EY to act as our independent registered public accounting firm and to audit our financial statements for the fiscal year ending December 31, 2022. EY has served as our independent registered public accounting firm and audited our financial statements since 2018.

To help ensure auditor independence, our audit committee reviews EY’s independence and performance on an annual basis as part of its decision whether to continue to engage EY as the company’s independent auditor. In the course of its reviews, our audit committee considers, among other things, the following factors:

In addition, our audit committee is responsible for the oversight of the process to select, review, and evaluate EY’s lead audit partner, including by meeting with candidates for lead audit partner and engaging in discussions with company management.

Neither our bylaws nor other governing documents or law require stockholder ratification of the selection of EY as our independent registered public accounting firm. However, our audit committee is presenting this proposal to the stockholders for ratification as a matter of good corporate governance. In the event that this appointment is not ratified by our stockholders, our audit committee will consider that fact when it selects our independent auditors for the following fiscal year.

We expect that representatives of EY will attend the Annual Meeting. We will provide these representatives an opportunity to make a statement at the Annual Meeting if they desire to do so, and they will be available to respond to appropriate questions from stockholders.

Vote Required

The proposal to ratify the appointment of EY our independent registered public accounting firm for the year ending December 31, 2022 requires the affirmative vote of the majority of the votes cast at the Annual Meeting by the holders of the shares represented in person (via the Internet) or represented by proxy and entitled to vote on the proposal. Abstentions and broker non-votes will have no effect on the vote.

Our Recommendation

OUR BOARD UNANIMOUSLY RECOMMENDS A VOTE “FOR” THE RATIFICATION OF THE APPOINTMENT OF EY AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2022.

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Pre-Approval Policies and Procedures

Our audit committee pre-approves all audit services and non-audit services to be performed by our independent registered public accounting firm, EY, which may include audit-related services, tax services, and other services, and, in each case, the estimated fees for those services. The actual fees billed, to the extent they exceed the estimated amounts, are periodically reviewed and approved by our audit committee.

Our audit committee may delegate to one or more designated members of our audit committee the authority to grant required pre-approvals. The decisions of any member to whom authority is delegated to pre-approve services of EY shall be presented to our full audit committee at its next scheduled meeting. During our 2021 and 2020 fiscal years, all services provided by EY were pre-approved by our audit committee.

Independent Registered Public Accounting Firm Fees and Services

During the fiscal years ended December 31, 2021 and 2020, we retained EY to provide audit and other services. The following table represents aggregate fees billed or to be billed to us by EY for services performed for the fiscal years ended December 31, 2021 and 2020. All fees billed to us by EY for services performed for the fiscal years ended December 31, 2021 and 2020 were approved by our audit committee or a designated member of our audit committee in accordance with the pre-approval policies and procedures described above and applicable SEC rules and regulations.

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TRANSACTIONS WITH RELATED PERSONS

Policies and Procedures Regarding Transactions with Related Persons

In connection with our IPO, our Board adopted a policy in which our audit committee (or any other committee of our Board consisting of independent directors in the event it is inappropriate for our audit committee to review such transaction due to a conflict of interest) must review and approve all proposed related-person transactions. This review covers any transaction, arrangement, or relationship, or any series of similar transactions, arrangements or relationships, (x) in which we were or are to be a participant; (y) that is a material transaction, arrangement, or relationship, including if the amount involved exceeds $120,000; and (z) a related person had or will have a direct or indirect material interest, including purchases of goods or services by or from a related person or entities in which the related person has a material interest, and indebtedness, guarantees of indebtedness, and employment by us of a related person. In conducting any such review and determining whether to approve or reject the transaction, the audit committee (or other committee, as applicable) will consider the relevant facts and circumstances available and deemed relevant to our audit committee, including the commercial reasonableness of the terms of the transaction and the materiality and character of the related person’s direct or indirect interest in the transaction. A “related person” is any person who is or was one of our executive officers, directors, or director nominees, or is a holder of more than 5% of our common stock, or an immediate family member of or any entity owned or controlled by any of the foregoing persons.

Certain Related-Person Transactions

Since January 1, 2021, other than as described below, there have been no transactions or series of similar transactions to which we were a party or will be a party, and which qualified as a related-person transaction. All of the transactions described below were reviewed and approved by either our audit committee or another committee of our Board in accordance with the policy described above, except for those that occurred prior to the adoption of such policy.

We believe the terms obtained or consideration that we paid or received, as applicable, in connection with the transactions described below were comparable to terms available or the amounts that we would pay or receive, as applicable, in arm’s-length transactions.

Participation in our Initial Public Offering

Certain of our directors, executive officers, and 5% stockholders purchased shares of our common stock in our IPO at the initial public offering price. The following table sets forth the number of shares of our common stock purchased by executive officers, directors, holders of more than 5% of our capital stock (as of the time of purchase), and their affiliated entities or immediate family members and the aggregate purchase price paid for such shares.

Beam Therapeutics, Inc. Option and License Agreement

In October 2021, we entered into an Option and License Agreement (Beam License) with Beam, pursuant to which Beam granted us a non-exclusive license to use Beam’s proprietary CRISPR Cas12b nuclease editing technology, for a specified number of gene editing targets, to research, develop, and commercialize engineered cell therapy products that (i) are directed to certain antigen targets, with respect to our allogeneic T cell programs, or (ii) comprise certain human cell types, with respect to our stem cell-derived programs. We are permitted to use the CRISPR Cas12b system to modify or introduce, ex vivo, selected genetic sequences with

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respect to the licensed products under the Beam License. Pursuant to the Beam License, we paid Beam an upfront payment of $50.0 million. Additionally, we may be obligated to pay up to $65 million in specified developmental and commercial milestone payments and royalties on licensed products. At the time of the entry into the Beam License, Mr. Nelsen, a member of our Board, was a beneficial owner of greater than 10% of the outstanding shares of Beam. Mr. Nelsen is also affiliated with a member of the board of directors of Beam. In addition, Mr. Nelsen is affiliated with ARCH Venture Partners, which is a holder of greater than 5% of the outstanding shares of our common stock and greater than 5% of the outstanding shares of common stock of Beam, and was so affiliated at the time of our entry into the Beam License. For information regarding the Beam License, see “Business – Key Intellectual Property Agreements – Ex Vivo Cell Engineering Platform – License Agreement with Beam” included in Part I, Item I of our Annual Report. For more information regarding ARCH Venture Partners’ ownership in our securities and Mr. Nelsen’s relationship with ARCH Venture Partners, see the section of this proxy statement titled “Security Ownership of Certain Beneficial Owners and Management.”

Tome Biosciences, Inc. SAFE and Series A Preferred Stock Financing

In February 2021, we entered into a Simple Agreement for Future Equity (SAFE) with Tome Biosciences, Inc. (Tome) in the amount of $500,000, which SAFE was subject to automatic conversion into shares of preferred stock upon the closing of an equity financing by Tome. In October 2021, upon the closing of Tome’s Series A Preferred Stock Financing (the Tome Financing), pursuant to the terms of the SAFE, we received 624,952 shares of Series A Preferred Stock of Tome in exchange for the SAFE.

An affiliate of ARCH Venture Partners was the majority investor in the Tome Financing. Entities affiliated with ARCH Venture Partners hold greater than 5% of the outstanding shares of our common stock and greater than 5% of the outstanding shares of common stock of Tome, and had such ownership at the time of our entry into the SAFE and the closing of the Tome Financing. Mr. Nelsen is affiliated with ARCH Venture Partners. In addition, in connection with the closing of the Tome Financing, Dr. Harr was appointed to the board of directors of Tome. For more information regarding ARCH Venture Partners’ ownership in our securities and Mr. Nelsen’s relationship with ARCH Venture Partners, see the section of this proxy statement titled “Security Ownership of Certain Beneficial Owners and Management.”

Other Transactions

We have entered into various employment-related agreements and compensatory arrangements with our directors and executive officers that, among other things, provide for compensatory, including grants of stock option and restricted stock awards, and certain severance and change in control benefits. For a description of these arrangements, see the sections of this proxy statement titled “Executive Compensation – Narrative Disclosure to Summary Compensation Table – Long-Term Equity Incentive Awards,” “Executive Compensation – Narrative Disclosure to Summary Compensation Table – Employment Arrangements,” “Executive Compensation – Narrative Disclosure to Summary Compensation Table – Severance and Change in Control Benefits” and “Director Compensation – Cash and Equity Compensation.”

We have entered into indemnification agreements with each of our current directors and executive officers. Our indemnification agreements and obligations with respect to our current directors and executive officers are further described in the section of this proxy statement titled “Executive Compensation – Indemnification.”

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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth information regarding the beneficial ownership of shares of our common stock as of April 1, 2022 by (i) each named executive officer, (ii) each director and nominee for director, (iii) all directors and executive officers as a group, and (iv) each person, or group of affiliated persons, who is known by us to beneficially own more than 5% of our outstanding common stock. Other than as set forth in this table, we are not aware of any person or group that holds greater than 5% of our outstanding common stock.

Information with respect to beneficial ownership is based on information furnished to us by each director, executive officer, and stockholder who holds more than 5% of our outstanding common stock, and Schedules 13G or 13D filed with the SEC. Beneficial ownership of securities is determined according to the rules of the SEC and generally means, with respect to a security, that a person or entity possesses sole or shared voting or investment power of such security, including options and warrants that are currently exercisable or will be exercisable within 60 days of April 1, 2022. Options to purchase shares of our common stock that are exercisable within 60 days of April 1, 2022 are deemed to be beneficially owned by the person holding these options for the purpose of computing percentage ownership of that person, but they are not treated as outstanding for the purpose of computing any other person’s ownership percentage. Except as indicated in the footnotes below, each of the beneficial owners named in the table below has, to our knowledge, sole voting and investment power with respect to all shares of common stock listed as beneficially owned by such beneficial owner, except for shares owned jointly with that person’s spouse.

We have based our calculations of beneficial ownership on 189,572,571 shares of our common stock outstanding as of April 1, 2022.

Unless otherwise indicated, the address for each of the stockholders in the table below is c/o Sana Biotechnology, Inc., 188 East Blaine Street, Suite 400, Seattle, Washington 98102.

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SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

Delinquent Section 16(a) Reports

Section 16(a) of the Exchange Act requires our directors, executive officers, and persons who own more than 10% of our common stock to report to the SEC their initial ownership of our common stock and any subsequent changes in that ownership. The SEC has established specific due dates for these reports, and we are required to disclose in this proxy statement any late filings or failures to file.

Based solely on our review of such reports filed electronically with the SEC and written representations from reporting persons that no other reports were required during the fiscal year ended December 31, 2021, we believe that, during the 2021 fiscal year, all of our directors and executive officers complied with all Section 16(a) filing requirements applicable to them, except that an inadvertent late Form 4 report was filed for Dr. Harr on April 15, 2022 to report two transactions that occurred on April 14, 2021.

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SECURITIES AUTHORIZED FOR ISSUANCE UNDER EQUITY COMPENSATION PLANS

The following table sets forth the aggregate information of our equity compensation plans in effect as of December 31, 2021.

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HOUSEHOLDING OF PROXY MATERIALS

The SEC has adopted rules that permit companies and intermediaries (e.g., brokers) to satisfy the delivery requirements for proxy statements and annual reports with respect to two or more stockholders sharing the same address by delivering a single proxy statement addressed to those stockholders. This process, which is commonly referred to as “householding,” potentially means extra convenience for stockholders and cost savings for companies.

This year, several brokers with account holders who are our stockholders will be “householding” our Proxy Materials. A single set of Proxy Materials will be delivered to multiple stockholders sharing an address unless contrary instructions have been received from the affected stockholders. Once you have received notice from your broker that they will be “householding” communications to your address, “householding” will continue until you are notified otherwise or until you revoke your consent. If, at any time, you no longer wish to participate in “householding” and would prefer to receive a separate set of Proxy Materials, please notify your broker.

You may also request an additional proxy statement and Annual Report by sending a written request to:

Sana Biotechnology, Inc.

Attn: Corporate Secretary

188 East Blaine Street, Suite 400

Seattle, Washington 98102

(206) 701-7914

Stockholders who currently receive multiple copies of the proxy statement at their addresses and would like to request “householding” of their communications should contact their brokers.

OTHER MATTERS

We know of no other business that will be presented for consideration at the Annual Meeting other than as stated in the Notice of 2022 Annual Meeting of Stockholders. If, however, other matters are properly brought before the Annual Meeting, it is the intention of the persons named as proxies in the proxy card or voter instruction form, as applicable, to vote the shares represented thereby in accordance with the recommendation of our Board.

A copy of our proxy statement and Annual Report is available without charge upon written request to our Corporate Secretary, c/o Sana Biotechnology, Inc., 188 East Blaine Street, Suite 400, Seattle, Washington 98102.

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YOUR VOTE IS IMPORTANT! PLEASE VOTE BY: Sana Biotechnology, Inc. Annual Meeting of Stockholders For stockholders of record as of April 8, 2022 DATE: Monday, June 6, 2022 TIME: 9:00 AM, Pacific Time PLACE: The Annual Meeting will be a virtual meeting conducted via live audio webcast. Please visit www.proxydocs.com/SANA for registration details. This proxy is being solicited on behalf of the Board of Directors The undersigned hereby appoints Nathan Hardy and James J. MacDonald (the “Named Proxies”), and each or either of them, as the true and lawful attorneys of the undersigned, with full power of substitution and revocation, and authorizes them, and each of them, to vote all the shares of capital stock of Sana Biotechnology, Inc. which the undersigned is entitled to vote at said meeting and any adjournment or postponement thereof upon the matters specified and upon such other matters as may be properly brought before the meeting or any adjournment or postponement thereof, conferring authority upon such true and lawful attorneys to vote in their discretion on such other matters as may properly come before the meeting or any adjournment or postponement thereof and revoking any proxy heretofore given. THE SHARES REPRESENTED BY THIS PROXY WILL BE VOTED AS DIRECTED OR, IF NO DIRECTION IS GIVEN, SHARES WILL BE VOTED IN ACCORDANCE WITH THE BOARD OF DIRECTORS’ RECOMMENDATION. This proxy, when properly executed, will be voted in the manner directed herein. In their discretion, the Named Proxies are authorized to vote upon such other matters that may properly come before the meeting or any adjournment or postponement thereof. You are encouraged to specify your choice by marking the appropriate box (SEE REVERSE SIDE) but you need not mark any box if you wish to vote in accordance with the Board of Directors’ recommendation. The Named Proxies cannot vote your shares unless you sign (on the reverse side) and return this card. PLEASE BE SURE TO SIGN AND DATE THIS PROXY CARD AND MARK ON THE REVERSE SIDE P.O. BOX 8016, CARY, NC 27512-9903 INTERNET Go To: www.proxypush.com/SANA    Cast your vote online    Have your Proxy Card ready    Follow the simple instructions to record your vote PHONE Call 1-866-648-8136    Use any touch-tone telephone    Have your Proxy Card ready    Follow the simple recorded instructions MAIL    Mark, sign and date your Proxy Card    Fold and return your Proxy Card in the postage-paid envelope provided You must register at www.proxydocs.com/SANA in order to attend and participate in the Annual Meeting online.

Sana Biotechnology, Inc. Annual Meeting of Stockholders FOR each nominee for election for Proposal 1 and FOR Proposal 2 PROPOSAL YOUR VOTE BOARD OF DIRECTORS RECOMMENDS FOR WITHHOLD #P2# #P2# FOR #P3# #P3# FOR #P4# #P4# FOR #P5# #P5# FOR FOR AGAINST ABSTAIN 1. To elect four Class I directors to our Board of Directors, each to serve for a three-year term expiring at the 2025 annual meeting of stockholders. The four nominees for election are: 1.01 Douglas Cole, M.D. 1.02 Steven D. Harr, M.D. 1.03 Michelle Seitz, CFA 1.04 Patrick Y. Yang, Ph.D. 2. To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2022. #P6# #P6# #P6# FOR NOTE: Stockholders will also consider and act upon any other matters which may properly come before the Annual Meeting or any adjournment or postponement thereof. You must register at www.proxydocs.com/SANA in order to attend and participate in the Annual Meeting online. Authorized Signatures—Must be completed for your instructions to be executed. Please sign exactly as your name(s) appears on your account. If your shares are held in joint tenancy, all persons should sign. Trustees, administrators, etc., should include title and authority. Corporations should provide full name of corporation and title of authorized officer signing this proxy card. Signature (and Title if applicable) Proposal_Page—VIFL Date Signature (if held jointly) Date Please make your marks like this: X Use dark black pencil or pen only. THE BOARD OF DIRECTORS RECOMMENDS A VOTE: #P2# #P3# #P4# #P5#